Clinical attachment level (CAL) · Adults with aggressive periodontitis
Tetracycline + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -1.90 [-2.17, -1.63]
1 study · 26 participants
GRADE not reported
MD -2.30 [-2.50, -2.10]
1 study · 26 participants
Very low
MD -0.92 [-2.38, 0.54]
2 studies · 64 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Clindamycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -1.30 [-2.14, -0.46]
1 study · 21 participants
GRADE not reported
MD 0.40 [-0.35, 1.15]
1 study · 21 participants
GRADE not reported
MD -1.70 [-2.40, -1.00]
1 study · 21 participants
Very low
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
2 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -2.05 [-2.98, -1.11]
13 studies · 460 participants
GRADE not reported
MD -5.32 [-12.02, 1.37]
5 studies · 172 participants
GRADE not reported
MD -8.06 [-14.26, -1.85]
2 studies · 389 participants
Very low
Percentage of closed pockets · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Adverse events · Adults with aggressive periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in adverse events compared with tetracycline + SRP; GRADE not reported.
1 finding from 1 review
Patient-reported quality of life changes · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes percentage of closed pockets compared with SRP (very low certainty).
3 findings from 1 review
MD -12.20 [-29.23, 4.83]
1 study · 22 participants
Very low
MD -7.00 [-23.57, 9.57]
1 study · 22 participants
GRADE not reported
MD -2.56 [-12.33, 7.22]
2 studies · 51 participants
GRADE not reported
Probing pocket depth · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Antimicrobial resistance · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Clindamycin + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.40 [-0.22, 1.02]
1 study · 26 participants
GRADE not reported
MD 0.20 [-0.55, 0.95]
1 study · 26 participants
Very low
MD 0.10 [-0.60, 0.80]
1 study · 26 participants
GRADE not reported
Probing pocket depth · Adults with aggressive periodontitis
It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with doxycycline + SRP (very low certainty).
3 findings from 1 review
MD -0.80 [-1.58, -0.02]
1 study · 23 participants
Very low
MD 0.20 [-0.36, 0.76]
1 study · 23 participants
GRADE not reported
MD -0.40 [-1.14, 0.34]
1 study · 23 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.47 [-0.90, -0.05]
2 studies · 389 participants
Very low
MD -0.21 [-0.41, -0.01]
13 studies · 501 participants
GRADE not reported
MD -0.04 [-0.35, 0.26]
6 studies · 215 participants
GRADE not reported
Adverse events · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
1 finding from 1 review
All three included trials (Matarazzo 2008; Silva 2011; Xajigeorgiou 2006) reported adverse events in both MTZ + SRP and AMOX + MTZ + SRP groups (nausea, vomiting, diarrhoea, headache, metallic taste, irritability, mild…
3 studies · 84 participants
GRADE not reported