Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 89 findings · 8 reviews · Schizophrenia

No studies found 26 · 29.2%GRADE not reported 2 · 2.2%Very low 34 · 38.2%Low 27 · 30.3%Moderate 0 · 0%High 0 · 0%

COMPARISON 1. ARIPIPRAZOLE vs OLANZAPINE

Global state: No clinically important response (as defined by the original studies) · patients with schizophrenia

It is very uncertain whether COMPARISON 5. ARIPIPRAZOLE changes global state: No clinically significant response compared with OLANZAPINE (very low certainty).

1 finding from 1 review

COMPARISON 1. ARIPIPRAZOLE vs QUETIAPINE

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

COMPARISON 2. ARIPIPRAZOLE showed no clear difference in global state: No clinically significant response (as defined by… compared with QUETIAPINE (low certainty).

1 finding from 1 review

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + ARIPIPRAZOLE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + HALOPERIDOL (Cipriani 2013) (very low certainty).

1 finding from 1 review