Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails
Ciclopirox 8% lacquer showed no clear difference in adverse events (directly related to treatment, collected over the… compared with vehicle (low certainty).
1 finding from 1 review
Clinical cure ‐ not measured · People with fungal infections of the toenails
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of participants with complete cure · People with fungal infections of the toenails
It is very uncertain whether luliconazole 5% solution changes complete cure: 48 weeks compared with vehicle (very low certainty).
1 finding from 1 review
Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails
Luliconazole 5% solution showed no clear difference in adverse events (collected over the course of the studies; they are… compared with vehicle (low certainty).
1 finding from 1 review
Mycological cure · People with fungal infections of the toenails
Luliconazole 5% solution showed no clear difference in mycological cure: 48 weeks compared with vehicle (low certainty).
1 finding from 1 review
Clinical cure ‐ not measured · People with fungal infections of the toenails
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mycological cure · People with fungal infections of the toenails
Ciclopirox 8% lacquer probably leads to higher mycological cure: 48 weeks compared with vehicle (moderate certainty).
1 finding from 1 review
Clinical cure ‐ not measured · People with fungal infections of the toenails
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of participants with complete cure · People with fungal infections of the toenails
Efinaconazole 10% solution leads to higher complete cure: 40 to 52 weeks compared with vehicle (high certainty).
1 finding from 1 review
Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails
Efinaconazole 10% solution leads to higher adverse events (collected over the course of the studies; they are… compared with vehicle (high certainty).
1 finding from 1 review
Mycological cure · People with fungal infections of the toenails
Efinaconazole 10% solution probably leads to higher mycological cure: 40 to 52 weeks compared with vehicle (moderate certainty).
1 finding from 1 review
Cure · People with fungal infections of the toenails
Efinaconazole 10% solution leads to higher clinical cure: 40 to 52 weeks compared with vehicle (high certainty).
1 finding from 1 review
Proportion of participants with complete cure · People with fungal infections of the toenails
Tavaborole 5% solution probably leads to higher complete cure: 52 weeks compared with vehicle (moderate certainty).
1 finding from 1 review
Pruritus · chronic pruritus of unknown origin
Serlopitant 5 mg may leads to higher patient‐reported pruritus intensity compared with placebo (low certainty).
1 finding from 1 review
Sleep disturbances: number of participants with insomnia · chronic pruritus of unknown origin
It is very uncertain whether serlopitant 1 mg changes sleep disturbances: number of participants with insomnia compared with placebo (very low certainty).
1 finding from 1 review
Depression · chronic pruritus of unknown origin
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Patient satisfaction · chronic pruritus of unknown origin
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Pruritus · chronic pruritus of unknown origin
Serlopitant 0.25 mg showed no clear difference in patient‐reported pruritus intensity compared with placebo (low certainty).
1 finding from 1 review
Adverse events · chronic pruritus of unknown origin
It is very uncertain whether serlopitant 0.25 mg changes adverse events compared with placebo (very low certainty).
1 finding from 1 review
Health‐related quality of life · chronic pruritus of unknown origin
1 finding from 1 review