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Evidence found and GRADE certainty

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Intervention not reported

Adverse events · people with TSC

The intervention probably leads to higher adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Response to skin lesionsb · people with TSC

The intervention leads to higher response to skin lesionsb (high certainty).

1 finding from 1 review

Intervention not reported

Frequency of seizure · people with TSC

The intervention probably leads to higher frequency of seizure (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of participants with an increased creatinine level · people with TSC

The intervention probably leads to lower number of participants with an increased creatinine level (moderate certainty).

1 finding from 1 review

Intervention not reported

FEV1/FVC ratio · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events · people with TSC

The intervention leads to higher adverse events (high certainty).

1 finding from 1 review

Intervention not reported

50% reduction in tumour size · people with TSC

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Response to skin lesion · people with TSC

The intervention leads to higher response to skin lesion (high certainty).

1 finding from 1 review