L‐arginine vs placebo
Adverse effects · sickle cell disease
1 finding from 1 review
- no estimate extracted2 studies · 125 participantsGRADE not reported
Findings
What do systematic reviews say?
4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only
No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%
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L‐arginine vs placebo
Frequency of hospitalization (number of days in hospital) · sickle cell disease
It is very uncertain whether L‐arginine changes frequency of hospitalization (number of days in hospital) compared with placebo (very low certainty).
1 finding from 1 review
- no estimate extracted2 studies · 125 participantsVery low
L‐arginine vs placebo
Frequency of sickle cell‐related complications · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
L‐arginine vs placebo
Haemoglobin status · sickle cell disease
L‐arginine showed no clear difference in haemoglobin status (g/dL) compared with placebo (low certainty).
1 finding from 1 review
- MD 0.42 studies · 106 participantsLow
Omega‐3 vs placebo
Frequency of crisis · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
QoL of participants living with SCD and their caregivers · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Omega‐3 vs placebo
Severity of pain · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Omega‐3 vs placebo
QoL of participants living with SCD and their caregivers · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Omega‐3 vs placebo
Adverse effects (any adverse effect) · sickle cell disease
It is very uncertain whether omega‐3 changes adverse effects (any adverse effect) compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.05 [0.74, 1.48]1 study · 67 participantsVery low
Omega‐3 vs placebo
Frequency of hospitalization · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Omega‐3 vs placebo
Frequency of sickle cell‐related complications · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Omega‐3 vs placebo
Haemoglobin status · sickle cell disease
It is very uncertain whether omega‐3 changes haemoglobin status compared with placebo (very low certainty).
1 finding from 1 review
- MD 0.361 study · 67 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Adverse effects · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.56 [0.31, 1]1 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Frequency of hospitalization · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).
1 finding from 1 review
- RR 2.661 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Haemoglobin status · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
1 finding from 1 review
- no estimate extracted1 study · 83 participantsVery low
Zinc vs placebo
Frequency of crisis · people with sickle cell disease
Zinc showed no clear difference in frequency of crisis compared with placebo (low certainty).
1 finding from 1 review
- Rate ratio 0.62 [0.17, 2.29]1 study · 36 participantsLow
Zinc vs placebo
Severity of pain · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Escitalopram vs placebo
Severity of PTSD symptoms ‐ Clinician‐rated · adults experiencing acute traumatic stress symptoms
1 finding from 1 review
- Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… 2024 · Cochrane Headline outcomes onlyno estimate extracted1 study · 23 participantsVery low
Hydrocortisone vs placebo
Quality of life at 3 months · adults experiencing acute traumatic stress symptoms
1 finding from 1 review
- Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… 2024 · Cochrane Headline outcomes onlyno estimate extracted1 study · 43 participantsVery low