Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 884 findings · 229 reviews · Headline outcomes only

No studies found 136 · 15.4%GRADE not reported 37 · 4.2%Very low 242 · 27.4%Low 298 · 33.7%Moderate 131 · 14.8%High 40 · 4.5%

Intervention not reported

Functional Status Health Assessment Questionnaire Disability Index . Scale from: 0 to 3 · patients with rheumatoid arthritis
1 finding from 1 review

Cetirizine 10 to 20 mg vs placebo

Complete cessation of urticaria Global assessment of symptom scores · patients with chronic spontaneous urticaria

Cetirizine 10 to 20 mg may leads to higher complete suppression of urticaria Global assessment of symptom scores compared with placebo (low certainty).

1 finding from 1 review

Rupatadine 10 to 20 mg vs placebo

Good or excellent response Global assessment of symptom scores · patients with chronic spontaneous urticaria

Rupatadine 10 to 20 mg may leads to higher good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

1 finding from 1 review

Loratadine 10 mg vs placebo

Good or excellent response Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

1 finding from 1 review

Loratadine 10 mg vs desloratadine 5 mg

Good or excellent response: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

1 finding from 1 review

Loratadine 10 mg vs mizolastine 10 mg

Complete cessation of urticaria: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

It is very uncertain whether loratadine 10 mg changes complete cessation of urticaria: intermediate‐term duration of… compared with mizolastine 10 mg (very low certainty).

1 finding from 1 review