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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

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No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Oral care interventions (nurse-assisted toothbrushing, oral and pharyngeal cavity rinse, decontamination with antibiotics or antiseptics) vs usual care

Presence of related infection: pneumonia · people with stroke

Oral health care interventions showed no clear difference in presence of related infection: pneumonia (Analysis 1.7) compared with usual care (low certainty).

1 finding from 1 review

Oral care interventions (nurse-assisted toothbrushing, oral and pharyngeal cavity rinse, decontamination with antibiotics or antiseptics) vs usual care

Stroke survivor and providers' knowledge to OHC: knowledge (Analysis 1.8) · people with stroke

It is very uncertain whether oral health care interventions changes stroke survivor and providers' knowledge to OHC: knowledge (Analysis… compared with usual care (very low certainty).

1 finding from 1 review

Oral care interventions (nurse-assisted toothbrushing, oral and pharyngeal cavity rinse, decontamination with antibiotics or antiseptics) vs usual care

Stroke survivor and providers' attitudes to OHC: attitude (Analysis 1.11) · people with stroke

It is very uncertain whether oral health care interventions changes stroke survivor and providers' attitudes to OHC: attitude (Analysis… compared with usual care (very low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Proportion of children who had sedation failure after 1 dose of sedative agent · children undergoing neurodiagnostic procedures

Chloral hydrate oral (75 mg/kg) may leads to higher proportion of children who had sedation failure after 1 dose of… compared with pentobarbital intravenous (5 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Proportion of children who had sedation failure after 2 doses of sedative agent (same or different) · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (75 mg/kg) changes proportion of children who had sedation failure after 2 doses of… compared with pentobarbital intravenous (5 mg/kg) (very low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Non‐interpretable neuroimaging finding · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (75 mg/kg) changes non‐interpretable neuroimaging finding compared with pentobarbital intravenous (5 mg/kg) (very low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Number of children with clinical adverse event: oxygen desaturation · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (75 mg/kg) changes number of children with clinical adverse event: oxygen desaturation compared with pentobarbital intravenous (5 mg/kg) (very low certainty).

1 finding from 1 review

Chloral hydrate oral (60 mg/kg) vs music therapy

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (60 mg/kg) changes proportion of children who had sedation failure or inadequate level… compared with music therapy (very low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who successfully completed neurodiagnostic… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review