Findings

What do systematic reviews say?

2,191 questions · 2,354 findings · 362 reviews

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No studies found 323 · 13.7%GRADE not reported 382 · 16.2%Very low 555 · 23.6%Low 597 · 25.4%Moderate 345 · 14.7%High 152 · 6.5%

Prostacyclin vs control

Dyspnea · pulmonary arterial hypertension

1 finding from 1 review

Prostacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1521 participants
Low

Toric intraocular lens (IOL) vs limbal relaxing incisions (LRIs)

Visual acuity · people with astigmatism who are having cataract surgery (phacoemulsification)

1 finding from 1 review

Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 474 participants
Moderate

LABA/LAMA vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · Adults with COPD

1 finding from 1 review

Once daily long‐acting beta2‐agonists and long‐acting muscarinic antagonists in a combined inhaler versus placebo for… 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 4952 participants
High

Interventions for involving older patients with multi‐morbidity in decision‐making about their health care vs usual care

Patient enablement and engagement (b) Morisky Medication Adherence Scale at 15 months after baseline (8‐item yes‐no survey. Range of scores from 0 to 8. Lower scores suggest non‐adherence) (Morisky 2008) · older patients with multi‐morbidity

1 finding from 1 review

Interventions for involving older patients with multi‐morbidity in decision‐making during primary care consultations 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1546 participants
Moderate

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

Cost‐effectiveness · Children aged 6 years and older (healthy except for dental caries)

In children aged 6 years and older, the cost-effectiveness estimate was extremely imprecise and not significant (OR 0.00, 95% CI 0.00 to 48704.6; ungraded).

1 finding from 1 review

Clinical Effectiveness and Cost-Effectiveness of Oral-Health Promotion in Dental Caries Prevention among Children:… 2019 All outcomes
Community settings: home visits, telephone contacts, healthcare centers, and primary schools · Age >= 6 years
OR 0.00 [0.00, 48704.6]
2 studies
GRADE not reported

Bilateral extraction of compromised mandibular first permanent molars vs Age- and gender-matched non-extraction controls

Lower incisor inclination (lingual tipping and retrusion) · Children (approximately 11 years or older) with compromised mandibular first permanent molars

Bilateral lower first permanent molar extraction was associated with lingual tipping and retrusion of the lower incisors in one case-control study; ungraded.

1 finding from 1 review

Consequences of early extraction of compromised first permanent molar: a systematic review. 2018 All outcomes
Private clinics (Brazil)
Normando and Cavacami: lower incisor lingual tipping (1.NB mean 23.2 vs 28.4 degrees, P = 0.004) and retrusion (P = 0.03) after bilateral lower FPM loss. Table 3: Category III, Class C.
1 study
GRADE not reported

Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)

Oral health-related quality of life · Completely edentulous people

Alginate (two stage-two step final/wash impression) may leads to higher participant-reported oral health-related quality of life… compared with silicone elastomer (two stage-two step) (low certainty).

1 finding from 1 review

Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes
2 weeks
MD 7.20 [2.71, 11.69]
1 study · 144 participants
Low

Epidural vs opioid

Maternal pain score measured during labour · women in labour

1 finding from 1 review

Epidural versus non‐epidural or no analgesia for pain management in labour 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1133 participants
Low

Phototherapeutic keratectomy vs alcohol delamination

Painiv, SD units(lower scores indicate less pain) · people with recurrent corneal erosion syndrome without previous surgical intervention

1 finding from 1 review

Interventions for recurrent corneal erosions 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Low

Antibiotics vs placebo or usual care

Symptom score at 10 days. Measured on a 7‐point scale (0 to 6) ; lower score denotes fewer symptoms · acute asthma exacerbation

1 finding from 1 review

Antibiotics for exacerbations of asthma 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2 participants
Moderate

Altered WBRT fractionation schedules vs WBRT control

Overall survival: higher‐dose WBRT vs control (3000 cGy/10 daily fractions)No. of participants: 846(4 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules probably leads to higher overall survival: lower‐dose WBRT vs control WBRT (3000 cGy/10 daily… compared with WBRT control (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
HR 1.21 [1.04, 1.4]
Studies not reported
Moderate

Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Neurological function improvement: lower‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1612(5 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules probably leads to higher neurological function improvement: lower‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
OR 1.74 [1.06, 2.84]
Studies not reported
Moderate

Intervention not reported

Pain: 50% reduction in headache frequency Post‐treatment Lower scores = fewer headaches · Children and adolescents with chronic pain

It is very uncertain whether the intervention changes pain: 50% reduction in headache frequency Post‐treatment Lower… (very low certainty).

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
RR 2.35 [1.67, 3.3]
15 studies · 644 participants
Very low

Intervention not reported

Disability Post‐treatment Lower scores = lower reported disability · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 1226 participants
Low

Intervention not reported

Anxiety Post‐treatment Lower scores = lower reported anxiety · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 883 participants
Low

Intervention not reported

Depression Post‐treatment Lower scores = lower reported depression · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 757 participants
Very low

Intervention not reported

Disability Post‐treatment Lower scores = lower reported disability · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 446 participants
Very low

Intervention not reported

Anxiety Post‐treatment Lower scores = lower reported anxiety · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 439 participants
Very low

Intervention not reported

Depression Post‐treatment Lower scores = lower reported depression · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 400 participants
Very low

Intervention not reported

Pain Post‐treatment Lower scores = lower reported pain intensity · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 1210 participants
Very low