Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

551 questions · 579 findings · 72 reviews · Headline outcomes only

No studies found 158 · 27.3%GRADE not reported 44 · 7.6%Very low 173 · 29.9%Low 112 · 19.3%Moderate 66 · 11.4%High 26 · 4.5%

Intervention not reported

Mortality or tracheostomy at 12 months (pooled hazard ratio)(riluzole 100 mg) · patients with ALS/MND

The intervention showed no clear difference in mortality or tracheostomy at 12 months (pooled hazard… (high certainty).

1 finding from 1 review

Intervention not reported

Per cent mortality at 12 months (riluzole 100 mg) · patients with ALS/MND

The intervention leads to lower per cent mortality at 12 months (riluzole 100 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Adverse event: 3‐fold increase in alanine transferase · patients with ALS/MND

The intervention leads to higher adverse event: 3‐fold increase in alanine transferase (high certainty).

1 finding from 1 review