Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

777 questions · 792 findings · 40 reviews · Kidney and Transplant

No studies found 232 · 29.3%GRADE not reported 3 · 0.4%Very low 218 · 27.5%Low 253 · 31.9%Moderate 76 · 9.6%High 10 · 1.3%

Probiotics vs antibiotic prophylaxis

Renal parenchymal defects on DMSA scan ‐ Patient data at 1 year · primary VUR

Probiotics showed no clear difference in renal parenchymal defects on DMSA scan ‐ Patient data at 1 year compared with antibiotic prophylaxis (low certainty).

1 finding from 1 review

Surgical reimplantation of ureters plus antibiotics vs antibiotics alone

Febrile UTI by 5 years: surgical correction + antibiotics versus antibiotics alone · primary VUR

Surgical reimplantation of ureters plus antibiotics probably leads to lower febrile UTI by 5 years: surgical correction + antibiotics versus… compared with antibiotics alone (moderate certainty).

1 finding from 1 review

Calcineurin inhibitor vs IV cyclophosphamide

Adverse events: treatment failure (non response, serious infection, persistently elevated creatinine) at 6 months · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: treatment failure at 6 months (non response, serious… compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review

Calcineurin inhibitor vs IV cyclophosphamide

Discontinuation of medication due to adverse events · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: medications ceased due to adverse events compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review