Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,036 questions · 1,100 findings · 261 reviews

No studies found 160 · 14.5%GRADE not reported 188 · 17.1%Very low 270 · 24.5%Low 303 · 27.5%Moderate 139 · 12.6%High 40 · 3.6%

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in physician‐assessed improvement in rosacea severity Investigator's… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Assessment of erythema or telangiectasia Improved or healed · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in assessment of erythema or telangiectasia Improved or healed compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Topical ivermectin vs placebo

Assessment of erythema or telangiectasia ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Topical brimonidine vs vehicle

Participant‐assessed improvement in rosacea severity Patient Satisfaction Assessment ‐ grade 2 improvement · Participants with rosacea
1 finding from 1 review

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Assessment of erythema or telangiectasia · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel showed no clear difference in assessment of erythema or telangiectasia compared with placebo (moderate certainty).

1 finding from 1 review