Findings

What do systematic reviews say?

577 questions · 585 findings · 77 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 143 · 24.4%GRADE not reported 26 · 4.4%Very low 145 · 24.8%Low 156 · 26.7%Moderate 98 · 16.8%High 17 · 2.9%

Summary of findings ‐ PEP vs oscillating PEP

Direct measures of mucus clearance · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs oscillating PEP

Exercise capacity · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 68 participants
Moderate

Summary of findings ‐ PEP vs oscillating PEP

General well‐being · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 75 participants
Low

Summary of findings ‐ PEP vs oscillating PEP

LCI · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Summary of findings ‐ PEP vs oscillating PEP

Adverse events · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
22 participants
Low

Summary of findings ‐ PEP vs HFCWO

Pulmonary exacerbations · adults and children with CF

Summary of findings ‐ PEP leads to lower number of respiratory exacerbations compared with HFCWO (high certainty).

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
RR 0.73 [0.55, 0.95]
1 study · 107 participants
High

Summary of findings ‐ PEP vs HFCWO

Direct measures of mucus clearance · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs HFCWO

Exercise capacity · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs HFCWO

General well‐being · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs PDPV

Pulmonary exacerbations · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Low

Summary of findings ‐ PEP vs HFCWO

LCI · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
15 participants
Very low

Summary of findings ‐ PEP vs HFCWO

Adverse events · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 107 participants
High

Summary of findings ‐ PEP vs BiPAP

FEV1 · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 52 participants
Low

Summary of findings ‐ PEP vs BiPAP

Pulmonary exacerbations · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs BiPAP

Direct measures of mucus clearance · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs BiPAP

Exercise capacity · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Low

Summary of findings ‐ PEP vs BiPAP

General well‐being · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs BiPAP

LCI · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Low

Summary of findings ‐ PEP vs BiPAP

Adverse events · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
20 participants
Low

Summary of findings ‐ PEP vs PDPV

Direct measures of mucus clearance: radio‐labelled aerosol clearance · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
20 participants
Low