Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intravenous dexamethasone vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Intravenous dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review

Intentional endometrial injury vs no intervention or a sham procedure

Live birth · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)

Intentional endometrial injury showed no clear difference in live birth (primary analysis) compared with no intervention or a sham procedure (low certainty).

1 finding from 1 review

Intentional endometrial injury vs no intervention or a sham procedure

Live birth or ongoing pregnancy · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)

It is very uncertain whether intentional endometrial injury changes live birth or ongoing pregnancy (sensitivity analysis) compared with no intervention or a sham procedure (very low certainty).

1 finding from 1 review

Intentional endometrial injury vs no intervention or a sham procedure

Clinical pregnancy · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)
2 findings from 1 review

Endometrial resection or ablation vs unspecified (or at surgeon's discretion) route of hysterectomy

Effectiveness Proportion of women with perception of improvement of bleeding symptoms · heavy menstrual bleeding

Endometrial resection/ablation may leads to lower effectiveness Proportion of women with perception of improvement of… compared with unspecified (or at surgeon's discretion) route of hysterectomy (low certainty).

1 finding from 1 review

Endometrial resection or ablation vs unspecified (or at surgeon's discretion) route of hysterectomy

Proportion with improvement in general health · heavy menstrual bleeding

Endometrial resection/ablation may leads to lower proportion with improvement in general health compared with unspecified (or at surgeon's discretion) route of hysterectomy (low certainty).

1 finding from 1 review

Endometrial resection or ablation vs unspecified (or at surgeon's discretion) route of hysterectomy

Acceptability Proportion satisfied with treatment · heavy menstrual bleeding

Endometrial resection/ablation showed no clear difference in acceptability Proportion satisfied with treatment compared with unspecified (or at surgeon's discretion) route of hysterectomy (moderate certainty).

1 finding from 1 review

Endometrial resection or ablation vs unspecified (or at surgeon's discretion) route of hysterectomy

Safety Any serious adverse event · heavy menstrual bleeding

Endometrial resection/ablation probably leads to lower safety Any serious adverse event compared with unspecified (or at surgeon's discretion) route of hysterectomy (moderate certainty).

1 finding from 1 review

Bacillus Calmette‐Guérin (BCG) vs mitomycin

Overall survival (absolute effect size estimates based on survival rate at 24 months)

Bacillus Calmette‐Guérin (BCG) showed no clear difference in time to death from any cause (absolute effect size estimates based… compared with mitomycin C (MMC) (low certainty).

1 finding from 1 review