Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

SCS treatment for 7 or fewer days vs SCS treatment

Adverse drug effects Gastrointestinal tract bleeding, symptomatic gastrointestinal reflux, symptoms of congestive heart failure or ischaemic heart disease, sleep disturbance, fractures, depression · exacerbations of COPD

SCS treatment for 7 or fewer days showed no clear difference in adverse drug effects Gastrointestinal tract bleeding, symptomatic… compared with SCS treatment (low certainty).

1 finding from 1 review

Xylitol sucking tablets (1 g/day) vs no treatment

Number of infants with a caries increment · Infants/young children (primary teeth; baseline about 1 to 3 years)

Xylitol sucking tablets (1 g/day) showed no clear difference in number of infants with a caries increment compared with no treatment; GRADE not reported.

1 finding from 1 review

Mifepristone (10 mg/day/3 months) vs placebo

Relief of pelvic paindichotomic · patients with uterine fibroids

Mifepristone (10 mg/day/3 months) showed no clear difference in relief of pelvic paindichotomic compared with placebo (low certainty).

1 finding from 1 review

Azithromycin (500 mg 20 ‐ 28 days) vs meglumine antimoniate (15 ‐ 20 mg/kg/d

Complete cure, at least 3 months after the end of treatment · People with American cutaneous and mucocutaneous leishmaniasis

Azithromycin (500 mg 20 ‐ 28 days) probably leads to lower complete cure, at least 3 months after the end of treatment compared with meglumine antimoniate (15 ‐ 20 mg/kg/d (moderate certainty).

1 finding from 1 review