Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,125 questions · 1,173 findings · 91 reviews · Headline outcomes only

No studies found 192 · 16.4%GRADE not reported 47 · 4%Very low 199 · 17%Low 325 · 27.7%Moderate 271 · 23.1%High 139 · 11.8%

Probiotics vs other active intervention

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

It is very uncertain whether probiotics changes requiring rescue medication for diarrhoea compared with other active treatment (very low certainty).

1 finding from 1 review

Probiotics vs placebo

Median (mean) time to use of rescue medication · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

Requiring rescue medication for diarrhoea · participants with cancer treated with radiotherapy (with or without chemotherapy)

Probiotics showed no clear difference in requiring rescue medication for diarrhoea compared with placebo (moderate certainty).

2 findings from 1 review

Probiotics vs placebo

Adverse events · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Probiotics vs placebo

All‐cause mortality · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Moxibustion vs no treatment

The incidence and severity of toxicities: leukopenia (WHO grade 3 to 4) · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion showed no clear difference in the incidence and severity of toxicities: leukopenia (WHO grade 3 to… compared with no treatment (low certainty).

1 finding from 1 review

Moxibustion vs Western medicine

The incidence and severity of toxicities: haematological toxicity · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion showed no clear difference in the incidence and severity of toxicities: haematological toxicity compared with conventional medicines (low certainty).

1 finding from 1 review