Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,016 questions · 2,067 findings · 222 reviews · Headline outcomes only

No studies found 471 · 22.8%GRADE not reported 108 · 5.2%Very low 570 · 27.6%Low 458 · 22.2%Moderate 363 · 17.6%High 97 · 4.7%

Topical antibiotics vs antiseptic agent

Allergic contact dermatitis · people presenting for surgery where healing of surgical wound planned to be by primary intention

It is very uncertain whether topical antibiotics changes allergic contact dermatitis compared with antiseptic (very low certainty).

1 finding from 1 review

Systemic antibiotics alone vs systematic antibiotics plus antibiotic lock solution

Cure: successful eradication of the infection · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics alone changes cure: successful eradication of the infection compared with systematic antibiotics plus antibiotic lock solution (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment or placebo on top of topical antiseptics

Resolution of ear discharge ‐ measured after 4 weeks · schoolchildren with CSOM

It is very uncertain whether systemic antibiotics changes resolution of ear discharge (4 weeks or more) ‐ measured at 3 to 4… compared with no treatment or placebo on top of topical antiseptics (very low certainty).

1 finding from 1 review