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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,590 questions in 129 reviews · Gynaecological, Neuro-oncology and Orphan Cancer
current versionsNo studies 281 · 17.7%Ungraded 74 · 4.7%Very low 410 · 25.8%Low 420 · 26.4%Moderate 280 · 17.6%High 125 · 7.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings: Bile acid sequestrants vs no intervention QOL scores · People with pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Misoprostol vs placebo Outcomes1 · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Misoprostol vs placebo Mean GI symptom scores · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Misoprostol vs placebo Acute and late GI toxicity (grade 2+) · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 1.38 [0.76, 2.51] | 1 study · 100 participants | Low |
Summary of findings: Misoprostol vs placebo Diarrhoea (grade 2+) · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 1 [0.46, 2.19] | 1 study · 100 participants | Very low |
Summary of findings: Misoprostol vs placebo QOL scores · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: IMRT vs 3DCRT Diarrhoea (grade 2+) · People with urological (prostate) and gynaecological (cervical) cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 0.38 [0.22, 0.68] | 1 study · 72 participants | Low |
Summary of findings: Magnesium oxide vs placebo Mean GI symptom scores (during RT) · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Magnesium oxide vs placebo Acute and late GI toxicity (grade 2+) · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 1.7 [0.87, 3.31] | 1 study · 92 participants | Moderate |
Summary of findings: Magnesium oxide vs placebo Diarrhoea (grade 2+) · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Magnesium oxide vs placebo QOL scores · Men with prostate cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Octreotide vs placebo Outcomes1 · People undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Octreotide vs placebo Mean GI symptom scores · People undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Octreotide vs placebo Acute and late GI toxicity (grade 2+) · People undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Octreotide vs placebo Diarrhoea (grade 2+) · People undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 1.01 [0.76, 1.35] | 2 studies · 340 participants | Moderate |
Summary of findings: Octreotide vs placebo QOL scores · People undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Diet interventions vs usual on‐treatment diet Elemental diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: IMRT vs 3DCRT QoL scores · People with urological (prostate) and gynaecological (cervical) cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Summary of findings: Diet interventions vs usual on‐treatment diet Mean GI symptom scores (IBDQ‐B) (higher scores better) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | 1 study · 50 participants | Low |
Summary of findings: Diet interventions vs usual on‐treatment diet Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Diet interventions vs usual on‐treatment diet Diarrhoea (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 0.79 [0.45, 1.38] | 1 study · 50 participants | Low |
Summary of findings: Diet interventions vs usual on‐treatment diet QOL scores (IBDQ) (higher scores better) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | MD 4.6 | 1 study · 50 participants | Low |
Summary of findings: Diet interventions vs usual on‐treatment diet Lactose‐restricted diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Diet interventions vs usual on‐treatment diet Diarrhoea (grade 1+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 0.74 [0.45, 1.23] | 1 study · 119 participants | Low |
Summary of findings: Diet interventions vs usual on‐treatment diet QOL scores (QLQ‐PR25) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | 1 study · 119 participants | Ungraded |
Summary of findings: Diet interventions vs usual on‐treatment diet High‐fibre diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Diet interventions vs usual on‐treatment diet Low‐fibre diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Diet interventions vs usual on‐treatment diet Low‐fat diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: BT vs EBRT Mean GI symptom scores · People with urological (prostate) and gynaecological (endometrial) cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | 1 study · 348 participants | Ungraded |
Summary of findings: Diet interventions vs usual on‐treatment diet Mean GI symptom scores (Vaizey scale) (higher scores better) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | 1 study · 70 participants | Low |
Summary of findings: Diet interventions vs usual on‐treatment diet Diarrhoea · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Diet interventions vs usual on‐treatment diet QOL scores (IBDQ) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | MD 2.4 | 1 study · 76 participants | Low |
Summary of findings: Diet interventions vs usual on‐treatment diet Prebiotic diet · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Protein supplements vs no intervention Mean GI symptom scores (lower is better) · Individuals undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Protein supplements vs no intervention Acute and late GI toxicity (grade 2+) · Individuals undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Protein supplements vs no intervention Diarrhoea (grade 2+) · Individuals undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | RR 0.53 [0.27, 1.03] | 1 study · 74 participants | Very low |
Summary of findings: Protein supplements vs no intervention QOL scores · Individuals undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Probiotics vs control (placebo or no intervention) Mean GI symptom scores · People undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: Probiotics vs control (placebo or no intervention) Acute and late GI toxicity (grade 2+) · People undergoing RT for pelvic cancer Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary… (2018) · Cochrane | no estimate extracted | NR | No studies |
iMRI image‐guided surgery vs standard surgery Adverse events · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
Neuronavigation image‐guided surgery vs standard surgery Overall survival · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
Neuronavigation image‐guided surgery vs standard surgery Progression‐free survival · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
Neuronavigation image‐guided surgery vs standard surgery Quality of life · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
iMRI image‐guided surgery vs standard surgery Overall survival · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
iMRI image‐guided surgery vs standard surgery Progression‐free survival · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
iMRI image‐guided surgery vs standard surgery Quality of life · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
5‐ALA image‐guided surgery vs standard surgery Adverse events · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
5‐ALA image‐guided surgery vs standard surgery Overall survival · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
5‐ALA image‐guided surgery vs standard surgery Progression‐free survival · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |
5‐ALA image‐guided surgery vs standard surgery Quality of life · high‐grade glioma Intraoperative imaging technology to maximise extent of resection for glioma (2018) · Cochrane | no estimate extracted | NR | No studies |