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Evidence found and GRADE certainty

550 questions · 581 findings · 23 reviews · Implants and prosthodontics

No studies found 87 · 15%GRADE not reported 388 · 66.8%Very low 88 · 15.1%Low 10 · 1.7%Moderate 8 · 1.4%High 0 · 0%

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Prosthesis failure · People with dental implants

1-stage (non-submerged) implant placement showed no clear difference in prosthesis failure compared with 2-stage (submerged) implant placement (moderate certainty).

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Marginal bone level change · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in 1-year post-loading bone level changes compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

2 findings from 1 review

Effervescent tablets vs No treatment (immersion in distilled water)

Microbial counts (total aerobes, anaerobes, yeasts) · Complete denture (CD) wearers in a nursing home
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Moore 1984: soaking methods resulted in significant reduction of total aerobes and anaerobes versus distilled water (paired t test, P < 0.05); three soaking methods (Clorox and Calgon, Polident, Effedent) were less…
    1 study · 12 participants
    GRADE not reported

Brushing vs Effervescent tablets

Visual plaque score · American complete denture (CD) wearers
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    12 weeks
    Tarbet 1984 compared brushing with two types of effervescent tablets. No standard deviations were reported and therefore no data were entered for this outcome. Brushing was associated with significantly lower plaque…
    1 study · 75 participants
    GRADE not reported

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Major complications · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in major complications compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Enzyme cleanser vs Placebo / sham solution

Microbial counts (hyphae and bacteria) · Institutionalised elderly wearing maxillary complete dentures (CD)
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    12 weeks
    Lower hyphal and bacterial scores were also found for 'E' when compared with 'Plac' after 12 weeks. It was not possible to extract adequate data as the investigators did not provide standard deviations.
    1 study
    GRADE not reported

Enzyme cleanser vs Brushing

Denture plaque · Wearers of maxillary and mandibular complete dentures (CD)
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Standard deviations were not reported for the relevant data so these were not included in the analysis. Reduction of plaque scores was associated with enzyme concentration (ANOVA, P < 0.001). Brushing alone and…
    1 study
    GRADE not reported

Autogenous bone block from the chin + resorbable barrier vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Prosthesis/implant failure (1 year) · Patients with horizontally resorbed maxillary sites needing single implants

Autogenous bone block from the chin + resorbable barrier showed no clear difference in prosthesis/implant failure (1 year) compared with 100% Bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Any denture cleansing method (mechanical or chemical) vs Another therapy, placebo, or no treatment

Adverse effects · Adults (over 18) wearing complete dentures (CD) or removable partial dentures (RPD)

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Noticeable absence of reports about adverse effects; no included study assessed the extent of adverse effects (for example the aftertaste of sodium hypochlorite, or mechanical or chemical damage to denture materials)…
    0 studies
    No studies found

Silicone surfactant cleanser vs Placebo / sham solution

Visual plaque score · Complete denture (CD) wearers

Silicone surfactant cleanser led to lower visual plaque score compared with placebo / sham solution; GRADE not reported.

2 findings from 1 review

Vertical GBR with non-resorbable titanium-reinforced barriers vs Vertical GBR with resorbable barriers supported by osteosynthesis plates

Complication at augmented site · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with non-resorbable titanium-reinforced barriers showed no clear difference in complication at augmented site compared with vertical GBR with resorbable barriers supported by osteosynthesis…; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

No improvement of facial appearance (3 weeks) · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to lower no improvement of facial appearance (3 weeks) compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Horizontal bone augmentation (any technique) vs No augmentation

Outcome not reported · Patients with horizontally resorbed maxillary sites needing single implants

The review found no eligible studies for this question.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Prosthetic failure (2 years) · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in prosthetic failure compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Enzyme cleanser vs Placebo / sham solution

Improvement on denture cleanliness (caregivers' opinion) · Institutionalised elderly wearing maxillary complete dentures (CD)

Enzyme cleanser led to lower improvement on denture cleanliness (caregivers' opinion) compared with placebo / sham solution; GRADE not reported.

1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    12 weeks
    After 12 weeks using an enzyme denture cleanser ('E'), 8 of 18 caregivers perceived some improvement in CD cleanliness. After using a placebo solution ('Plac'), only 2 of 17 perceived some improvement (Analysis 1.1,…
    1 study · 35 participants
    GRADE not reported

Ultrasound during vertical distraction osteogenesis vs Placebo (no ultrasound) during vertical distraction

Distraction distance (bone gain, mm) · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Ultrasound during vertical distraction osteogenesis showed no clear difference in distraction distance (bone gain, mm) compared with placebo (no ultrasound) during vertical distraction; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs Association of brushing and effervescent tablets

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets showed no clear difference in total anaerobes (colony forming units, log-transformed) compared with association of brushing and effervescent tablets; GRADE not reported.

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous inlay bone graft (iliac crest)

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis led to higher vertical bone gain compared with autogenous inlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review