Deaths · children with SCD
Summary of findings ‐ initiation of penicillin prophylaxis showed no clear difference in deaths compared with placebo (low certainty).
1 finding from 1 review
Adverse effects · children with SCD
1 finding from 1 review
Antibiotic‐resistant organisms isolated · children with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Requirement of other courses of antibiotics · children with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Compliance with treatment · children with SCD
1 finding from 1 review
Incidence of S pneumoniae Confirmed bacterial infection · children with SCD who have been receiving prophylactic penicillin for at least two years
Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in incidence of S pneumoniae Confirmed bacterial infection compared with continuation (low certainty).
1 finding from 1 review
Deaths · children with SCD who have been receiving prophylactic penicillin for at least two years
1 finding from 1 review
Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years
Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).
1 finding from 1 review
Radiological diagnosis of DIOS (physician‐measured radiological scores) · adults and children with cystic fibrosis
1 finding from 1 review
Adverse effects (participant interviews) · adults and children with cystic fibrosis
1 finding from 1 review
Total gastrointestinal symptom scores (participant‐reported symptom scores from 20 to 100) · adults and children with cystic fibrosis
1 finding from 1 review
Hospitalisation (any cause) · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hospitalisation for DIOS · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Tolerability · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Number of joint bleeding episodes per year (AJBR) · children or adults with hemophilia A or B
1 finding from 1 review
Intervention not reported
Number of total bleeds per year (ABR) · children or adults with hemophilia A or B
1 finding from 1 review
Intervention not reported
Treatment‐related adverse events · children or adults with hemophilia A or B
1 finding from 1 review
Annualized joint Bleeding Rate (AjBR) · children or adults with hemophilia A
Prophylaxis with standard therapeutic factor concentrate showed no clear difference in AJBR compared with pegylated liposome FVIII formulation (low certainty).
1 finding from 1 review
ABR · children or adults with hemophilia A
Prophylaxis with standard therapeutic factor concentrate showed no clear difference in ABR compared with pegylated liposome FVIII formulation (low certainty).
1 finding from 1 review