Intervention not reported
Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration
The intervention led to higher composite: Preference for replacement over repair - Scenario 7:…; GRADE not reported.
1 finding from 1 review
RR 8.67 [5.32, 14.13]
11 studies
GRADE not reported
Intervention not reported
Composite: Preference for replacement over repair - Scenario 3: secondary caries
The intervention led to higher composite: Preference for replacement over repair - Scenario 3:…; GRADE not reported.
1 finding from 1 review
RR 2.28 [1.69, 3.08]
Studies not reported
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 5: open margin
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 5: open…; GRADE not reported.
1 finding from 1 review
RR 6.16 [5.32, 7.14]
7 studies
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 4: marginal discoloration
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 4:…; GRADE not reported.
1 finding from 1 review
RR 6.88 [4.77, 9.92]
6 studies
GRADE not reported
Intervention not reported
Composite: Preference for replacement over repair - Scenario 4: marginal discoloration
The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 4:…; GRADE not reported.
1 finding from 1 review
RR 1.44 [0.71, 2.91]
2 studies
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity
The intervention showed no clear difference in amalgam: Preference for replacement over repair - Scenario 8:…; GRADE not reported.
1 finding from 1 review
RR 2.12 [0.66, 6.82]
2 studies
GRADE not reported
Virulence-gene expression related to adhesion acid production and exopolysaccharide synthesis · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro
No meta-analysis was conducted; the narrative synthesis reported reduced expression of Streptococcus mutans virulence genes.
1 finding from 1 review
Intervention not reported
Composite: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity
The intervention led to lower composite: Preference for replacement over repair - Scenario 8:…; GRADE not reported.
1 finding from 1 review
RR 0.39 [0.26, 0.58]
7 studies
GRADE not reported
Intervention not reported
Composite: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration
The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 1:…; GRADE not reported.
1 finding from 1 review
RR 0.29 [0.07, 1.21]
2 studies
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity
The intervention showed no clear difference in amalgam: Preference for replacement over repair - Scenario 8:…; GRADE not reported.
1 finding from 1 review
RR 0.88 [0.14, 5.56]
2 studies
GRADE not reported
Intervention not reported
Inhibition of S. sobrinus growth and biofilm formation (incl. ftf/gtfB/gtfC expression)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 3: secondary caries
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 3:…; GRADE not reported.
1 finding from 1 review
RR 7.62 [5.59, 10.38]
2 studies
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 7:…; GRADE not reported.
1 finding from 1 review
RR 12.93 [8.77, 19.05]
2 studies
GRADE not reported
Intervention not reported
Composite: Preference for replacement over repair - Scenario 5: open margin
The intervention led to higher composite: Preference for replacement over repair - Scenario 5: open…; GRADE not reported.
1 finding from 1 review
RR 4.04 [2.03, 8.06]
6 studies
GRADE not reported
Secondary prevention of caries · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis
Cavity liners may make little or no difference to secondary caries prevention (~100% prevention across groups; low certainty).
1 finding from 1 review
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 7:…; GRADE not reported.
1 finding from 1 review
RR 18.59 [7.66, 45.10]
11 studies
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 4: marginal discoloration
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 4:…; GRADE not reported.
1 finding from 1 review
RR 4.71 [2.97, 7.49]
2 studies
GRADE not reported
Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)
HIV-infected children on ART had higher odds of dental caries than HUU children in case-control studies (OR 1.61, 95% CI 1.02 to 2.56; ungraded).
2 findings from 1 review
Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a systematic review… 2025 All outcomesNot specified (case-control) · Dental examination of children/adolescents with HIV in clinic and community settings; low- and middle-income countries (Brazil, India, Nigeria, Cambodia, Uganda, West Africa) · Case-control studies
OR 1.61 [1.02, 2.56]
Studies not reported
GRADE not reported
Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a systematic review… 2025 All outcomesNot specified (cross-sectional) · Dental examination of children/adolescents with HIV in clinic and community settings; low- and middle-income countries (Brazil, India, Nigeria, Cambodia, Uganda, West Africa) · Cross-sectional studies
OR 1.80 [0.98, 3.28]
Studies not reported
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 6: corrosion
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 6:…; GRADE not reported.
1 finding from 1 review
RR 1.54 [1.03, 2.32]
10 studies
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 8:…; GRADE not reported.
1 finding from 1 review
RR 2.03 [1.35, 3.04]
6 studies
GRADE not reported