Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

764 questions · 795 findings · 110 reviews

No studies found 202 · 25.4%GRADE not reported 100 · 12.6%Very low 225 · 28.3%Low 155 · 19.5%Moderate 85 · 10.7%High 28 · 3.5%

Conventional occlusion vs atropine penalization

Visual acuity · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
2 findings from 1 review

Conventional occlusion vs atropine penalization

Ocular alignment (different measures and time points reported in the included studies) Assessed at different time points (17 weeks, 24 months, or cessation of treatment) and by the proportions of participants who developed strabismus, showed chang... · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Stereo acuity (different measures and time points reported in the included studies) Assessed at different time points (17 weeks, 6 months, 2 years, or at cessation of treatment) and using different measures (TNO stereo test, Titmus fly test, Rando... · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Quality of life (different measures and time points reported in the included studies) Assessed at different time points (17 weeks or 6 months) by patient preference or the Amblyopia Treatment Index questionnaire. · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Adverse events (reported occurrence of: mild reduction in the visual acuity of the sound eye not requiring treatment; light sensitivity; skin, lid, or conjunctival irritation) Assessed at different time points (17 weeks or 2 years). · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Active vs expectant management of the third stage of labour (all women)

Severe PPH (≥ 1000 mL) · all women who expected a vaginal birth at 24 weeks' gestation or later and their babies

It is very uncertain whether active changes severe primary PPH (clinically estimated or measured blood loss ≥… compared with expectant management of the third stage of labour (all women) (very low certainty).

1 finding from 1 review

Active vs expectant management of the third stage of labour (all women)

Maternal Hb < 9 g/dL 24‐72 hours postpartum · all women who expected a vaginal birth at 24 weeks' gestation or later and their babies

Active may leads to lower maternal Hb < 9 g/dL 24‐72 hours postpartum compared with expectant management of the third stage of labour (all women) (low certainty).

1 finding from 1 review

Active vs expectant management of the third stage of labour (all women)

Admission to SCBU/NICU · all women who expected a vaginal birth at 24 weeks' gestation or later and their babies

Active showed no clear difference in admission to SCBU/NICU compared with expectant management of the third stage of labour (all women) (low certainty).

1 finding from 1 review

Active vs expectant management of the third stage of labour (all women)

Neonatal jaundice requiring phototherapy or exchange transfusion · all women who expected a vaginal birth at 24 weeks' gestation or later and their babies

It is very uncertain whether active changes neonatal jaundice requiring phototherapy or exchange transfusion compared with expectant management of the third stage of labour (all women) (very low certainty).

1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Long-term skeletal relapse/stability (horizontal movement of A-point) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

It is very uncertain whether maxillary distraction osteogenesis changes long-term skeletal relapse/stability (horizontal movement of A-point) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Speech: resonance (hypernasality) (deterioration/improvement) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

It is very uncertain whether maxillary distraction osteogenesis changes speech: resonance (hypernasality) (deterioration/improvement) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Clinical morbidities (adverse effects) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…
1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Psychological status: social self-esteem (Culture-Free Self-Esteem Inventory subset); also general self-esteem and Social Avoidance and Distress Scale · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…
1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Midfacial soft tissue changes (facial profile landmarks: pronasale, subnasale, stomion superius, labrale superius) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

Maxillary distraction osteogenesis showed no clear difference in midfacial soft tissue changes (facial profile landmarks: pronasale,… compared with orthognathic surgery (conventional Le Fort I osteotomy); GRADE not reported.

1 finding from 1 review