Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

720 questions · 751 findings · 105 reviews

No studies found 193 · 25.7%GRADE not reported 37 · 4.9%Very low 212 · 28.2%Low 193 · 25.7%Moderate 99 · 13.2%High 17 · 2.3%

Extended‐fixed vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in endophthalmitis (ocular adverse event) compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

As needed may leads to lower gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Central retinal thickness μm (CRT) change at 1 year The aim of treatment is to reduce central retinal thickness so thinner is better. · people with neovascular age‐related macular degeneration
1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

As needed probably leads to lower endophthalmitis (ocular adverse event) compared with monthly injections (moderate certainty).

1 finding from 1 review

Extended‐fixed vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (moderate certainty).

1 finding from 1 review