Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

504 questions · 511 findings · 66 reviews

No studies found 104 · 20.4%GRADE not reported 26 · 5.1%Very low 107 · 20.9%Low 129 · 25.2%Moderate 107 · 20.9%High 38 · 7.4%

10 mg warfarin nomogram vs 5 mg warfarin nomogram

Major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or more units of red cells · patients with venous thromboembolism.

10 mg warfarin nomogram showed no clear difference in major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or… compared with 5 mg warfarin nomogram (moderate certainty).

1 finding from 1 review

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg

Proportion of participants who reported an adverse event · patients with hirsutism

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg showed no clear difference in proportion of participants who reported an adverse event compared with ethinyl estradiol 30 μg + desogestrel 0.15 mg (moderate certainty).

1 finding from 1 review

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Proportion of participants who reported an adverse event · women with hirsutism

It is very uncertain whether flutamide 250 mg once to twice daily changes proportion of participants who reported an adverse event compared with metformin 1275 mg to 1700 mg per day (very low certainty).

1 finding from 1 review

Loratadine 10 mg vs desloratadine 5 mg

Complete suppression of urticaria: intermediate‐term duration of intervention · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

1 finding from 1 review

Loratadine 10 mg vs desloratadine 5 mg

Good or excellent response: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

1 finding from 1 review