Findings

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Evidence found and GRADE certainty

511 questions · 561 findings · 70 reviews · Gynaecology and Fertility

No studies found 91 · 16.2%GRADE not reported 5 · 0.9%Very low 140 · 25%Low 219 · 39%Moderate 98 · 17.5%High 8 · 1.4%

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Fibrin sealant patch (collagen sponge with thrombin and fibrinogen) · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in fibrin sealant patch (collagen sponge with thrombin and fibrinogen) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Misoprostol vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Misoprostol showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (moderate certainty).

1 finding from 1 review

Vasopressin vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Vasopressin showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (moderate certainty).

1 finding from 1 review

Bupivicaine plus epinephrine vs placebo to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Bupivicaine plus epinephrine showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo to reduce blood loss during myomectomy (low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Misoprostol in abdominal myomectomy · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in misoprostol in abdominal myomectomy compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Gelatin‐thrombin matrix vs placebo or no treatment to reduce blood loss during myomectomy

Blood loss (ml) Estimated blood loss during myomectomy · women with uterine fibroids

Gelatin‐thrombin matrix showed no clear difference in blood loss (ml) Estimated blood loss during myomectomy compared with placebo or no treatment to reduce blood loss during myomectomy (low certainty).

1 finding from 1 review

Gelatin‐thrombin matrix vs placebo or no treatment to reduce blood loss during myomectomy

Blood transfusion · women with uterine fibroids

Gelatin‐thrombin matrix may leads to lower need for blood transfusion Participants who received blood transfusion compared with placebo or no treatment to reduce blood loss during myomectomy (low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Misoprostol in laparoscopic myomectomy · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in misoprostol in laparoscopic myomectomy compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Bupivicaine plus epinephrine · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in bupivicaine plus epinephrine compared with placebo or no treatment (low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Intravenous injection of tranexamic acid · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in intravenous injection of tranexamic acid compared with placebo or no treatment (low certainty).

1 finding from 1 review

Interventions to reduce blood loss during myomectomy for fibroids vs placebo or no treatment

Gelatin‐thrombin matrix · women with uterine fibroids

Interventions to reduce blood loss during myomectomy for fibroids showed no clear difference in gelatin‐thrombin matrix compared with placebo or no treatment (low certainty).

1 finding from 1 review