Δ9‐Tetrahydrocannabinol preparation showed no clear difference in participants experiencing adverse effects compared with placebo (moderate certainty).
N‐acetylcysteine showed no clear difference in participants abstinent at end of treatment compared with placebo (low certainty).
N‐acetylcysteine showed no clear difference in participants experiencing adverse effects compared with placebo (moderate certainty).
N‐acetylcysteine showed no clear difference in participants withdrawn due to adverse effects compared with placebo (low certainty).
N‐acetylcysteine showed no clear difference in completion of scheduled treatment compared with placebo (moderate certainty).
Δ9‐Tetrahydrocannabinol preparation showed no clear difference in participants withdrawn due to adverse effects compared with placebo (low certainty).
Δ9‐Tetrahydrocannabinol preparation showed no clear difference in completion of scheduled treatment compared with placebo (low certainty).
Selective serotonin reuptake inhibitor antidepressant showed no clear difference in participants abstinent at end of treatment compared with placebo (low certainty).
It is very uncertain whether selective serotonin reuptake inhibitor antidepressant changes participants experiencing adverse effects compared with placebo (very low certainty).
It is very uncertain whether selective serotonin reuptake inhibitor antidepressant changes participants withdrawn due to adverse effects compared with placebo (very low certainty).
It is very uncertain whether selective serotonin reuptake inhibitor antidepressant changes completion of scheduled treatment compared with placebo (very low certainty).
Mixed action antidepressant showed no clear difference in participants abstinent at end of treatment compared with placebo (low certainty).
Summary of findings table (subcomparison 4): targeted therapy agent… leads to lower overall survival compared with control intervention alone (high certainty).
Summary of findings table (subcomparison 4): targeted therapy agent… probably leads to lower progression‐free survival compared with control intervention alone (moderate certainty).
It is very uncertain whether summary of findings table (subcomparison 4): targeted therapy agent… changes toxicity compared with control intervention alone (very low certainty).
Summary of findings table (sensitivity analysis): interventions… showed no clear difference in studies with gastric cancer participants in addition to eligible… compared with gastric carcinoma; GRADE not reported.
It is very uncertain whether summary of findings table (sensitivity analysis): interventions… changes sensitivity analysis, meta‐regression analysis, first part compared with gastric carcinoma (very low certainty).
Summary of findings table (sensitivity analysis): interventions… led to lower sensitivity analysis, only esophageal and GE‐junction cancer… compared with gastric carcinoma; GRADE not reported.
Summary of findings table (sensitivity analysis): interventions… showed no clear difference in sensitivity analysis, only gastric cancer participants compared with gastric carcinoma; GRADE not reported.