Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,751 questions · 12,775 findings · 807 reviews · Headline outcomes only

No studies found 3,413 · 26.7%GRADE not reported 709 · 5.5%Very low 3,483 · 27.3%Low 3,165 · 24.8%Moderate 1,628 · 12.7%High 377 · 3%

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UAE/UACE vs MTX

Treatment success rate · women with CSP

UAE/UACE showed no clear difference in treatment success after initial treatment UAE vs systemic MTX compared with systemic MTX (low certainty).

1 finding from 1 review

UAE/UACE vs MTX

Complications UAE vs systemic MTX · women with CSP

UAE/UACE showed no clear difference in complications UAE vs systemic MTX compared with systemic MTX (low certainty).

1 finding from 1 review

UAE/UACE vs MTX

Adverse effects UAE vs systemic MTX · women with CSP

UAE/UACE showed no clear difference in adverse effects UAE vs systemic MTX compared with systemic MTX (low certainty).

1 finding from 1 review

Intervention not reported

Transepidermal water loss (TEWL) Measured using temperature‐adjusted g/m²/h with the Tewameter TM 300 (Courage + Khazaka, Cologne, Germany) Hahnel 2017: measured at 56 ± 4 days Shishido 2017: measured 15 minutes after wiping the skin with a dry to... · people 60 years of age and older
1 finding from 1 review

Intervention not reported

Stratum corneum hydration (SCH) (at baseline and day 56 ± 4) Hahnel 2017: measured at 56 ± 4 days in mid‐volar arm and lower leg in arbitrary units from 0 (no water) to 120 (on water) using the Corneometer CM 825 Gillis 2016: measured at 12 weeks ... · people 60 years of age and older
1 finding from 1 review

Intervention not reported

Clinical score of dryness Hahnel 2017: measured at day 56 ± 4 using the Overall Dry Skin Score Boccanfuso 1978: measured after 10 applications using a non‐validated General Foot Condition Questionnaire including a Dryness Scale (1 = oily; 2 = norm... · people 60 years of age and older
1 finding from 1 review

Oral nutritional supplements vs placebo

Ulcer healing · people with diabetes and foot ulcers

The review found no eligible studies for this question.

2 findings from 1 review

Arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement vs placebo

Development of any new foot ulcers · people with diabetes and foot ulcers

It is very uncertain whether arginine, glutamine and β‐hydroxy‐β‐methylbutyrate supplement changes development of any new foot ulcers compared with placebo (very low certainty).

1 finding from 1 review