What do systematic reviews say?

Dopamine agonist vs other active intervention

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 170 participants
  GRADE not reported

Dopamine agonist vs placebo or no intervention

Dopamine agonist showed no clear difference in live birth rate compared with placebo/no intervention (low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 0.96 [0.6, 1.55]
  3 studies · 362 participants
  Low

Dopamine agonist vs placebo or no intervention

Dopamine agonist showed no clear difference in miscarriage rate compared with placebo/no intervention (low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 0.66 [0.19, 2.28]
  2 studies · 168 participants
  Low

Dopamine agonist vs placebo or no intervention

It is very uncertain whether dopamine agonist changes any other adverse events compared with placebo/no intervention (very low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 4.54 [1.49, 13.84]
  2 studies · 264 participants
  Very low

Dopamine agonist plus co‐intervention vs co‐intervention

Dopamine agonist plus co‐intervention may leads to lower incidence of moderate or severe OHSS compared with co‐intervention (low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 0.48 [0.28, 0.84]
  4 studies · 748 participants
  Low

Dopamine agonist plus co‐intervention vs co‐intervention

Dopamine agonist plus co‐intervention showed no clear difference in live birth rate compared with co‐intervention (low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 1.21 [0.81, 1.8]
  2 studies · 400 participants
  Low

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

It is very uncertain whether antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) changes maternal sepsis compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (very low certainty).

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  RR 2.37 [0.1, 56.41]
  1 study · 75 participants
  Very low

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) showed no clear difference in maternal endometritis compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (low certainty).

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  RR 1.1 [0.76, 1.6]
  7 studies · 1161 participants
  Low

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

It is very uncertain whether antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) changes maternal wound infection compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (very low certainty).

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.78 [0.32, 1.9]
  4 studies · 543 participants
  Very low

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

It is very uncertain whether antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) changes maternal urinary tract infection compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (very low certainty).

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.64 [0.11, 3.73]
  4 studies · 496 participants
  Very low

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

It is very uncertain whether antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) changes maternal composite adverse effects compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (very low certainty).

• Different classes of antibiotics given to women routinely for preventing infection at caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.96 [0.09, 10.5]
  2 studies · 468 participants
  Very low

High levels of PEEP vs low levels of PEEP

High levels of PEEP showed no clear difference in mortality before hospital discharge compared with low levels of PEEP (moderate certainty).

• High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute… 2021 · Cochrane Headline outcomes only
  RR 0.97 [0.9, 1.04]
  7 studies · 3640 participants
  Moderate

High levels of PEEP vs low levels of PEEP

• High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 2594 participants
  Low

High levels of PEEP vs low levels of PEEP

• High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 2309 participants
  Low

High levels of PEEP vs low levels of PEEP

• High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1611 participants
  Moderate

High levels of PEEP vs low levels of PEEP

High levels of PEEP showed no clear difference in barotrauma compared with low levels of PEEP (low certainty).

• High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute… 2021 · Cochrane Headline outcomes only
  RR 1 [0.64, 1.57]
  9 studies · 3791 participants
  Low

High levels of PEEP vs low levels of PEEP

• High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1654 participants
  Low

Drainage vs no drainage after open appendectomy

It is very uncertain whether drainage changes intraperitoneal abscess compared with no drainage after open appendectomy (very low certainty).

• Abdominal drainage to prevent intra‐peritoneal abscess after appendectomy for complicated appendicitis 2021 · Cochrane Headline outcomes only
  RR 1.23 [0.47, 3.21]
  5 studies · 453 participants
  Very low