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What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

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No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Omega‐3 vs placebo

Diarrhoea · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes adverse events: diarrhoea compared with placebo (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

FEV1 % predicted · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes FEV1 % predicted compared with placebo (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

FVC · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes FVC % predicted compared with placebo (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Z score BMI · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes growth and nutrition: BMI SD score compared with placebo (very low certainty).

1 finding from 1 review

Rituximab vs placebo or control

Relapse · SSNS in children

Rituximab probably leads to lower relapses at 6 months compared with placebo or control (moderate certainty).

2 findings from 1 review

Alkylating agents vs steroids, placebo or both

Clinical relapse · SSNS in children

Alkylating agents probably leads to lower relapse at 6 to 12 months compared with steroids, placebo or both (moderate certainty).

2 findings from 1 review