Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Intervention not reported

All‐cause mortality · people with liver metastases

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Intervention not reported

Cancer mortality · people with liver metastases

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All adverse events and complications · people with liver metastases

The intervention led to higher all adverse events and complications; GRADE not reported.

1 finding from 1 review

Intervention not reported

Health‐related quality of life · people with liver metastases

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Recurrence of liver metastases Number of participants developing recurrences of liver metastases · people with liver metastases

The intervention showed no clear difference in recurrence of liver metastases Number of participants developing… (low certainty).

1 finding from 1 review

Intervention not reported

Time to progression of liver metastases · people with liver metastases

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Tumour response measures · people with liver metastases
1 finding from 1 review

Losigamone vs placebo

50% or greater reduction in seizure frequency · people with focal epilepsy

Losigamone probably leads to higher 50% or greater reduction in seizure frequency compared with placebo (moderate certainty).

1 finding from 1 review

Losigamone vs placebo

Treatment withdrawal · people with focal epilepsy

Losigamone probably leads to higher treatment withdrawal compared with placebo (moderate certainty).

1 finding from 1 review

Losigamone vs placebo

Proportion of participants experiencing adverse events · people with focal epilepsy

Losigamone showed no clear difference in the proportion of participants experiencing any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Infusion‐related reactions (number of participants with one or more reaction) · adults and children with mucopolysaccharidosis I

The intervention showed no clear difference in infusion‐related reactions (number of participants with one or more… (low certainty).

1 finding from 1 review

Intervention not reported

Antibody production: number of participants developing IgG antibodies · adults and children with mucopolysaccharidosis I

It is very uncertain whether the intervention changes antibody production: number of participants developing IgG antibodies (very low certainty).

1 finding from 1 review

Sulthiame add‐on vs placebo

50% or greater reduction in seizure frequency · patients between 3 to 15 months of age with West syndrome

The review found no eligible studies for this question.

1 finding from 1 review