Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 466 findings · 48 reviews · Schizophrenia

No studies found 87 · 18.7%GRADE not reported 82 · 17.6%Very low 153 · 32.8%Low 111 · 23.8%Moderate 19 · 4.1%High 14 · 3%

Paliperidone palmitate vs placebo

Leaving the study early · patients with schizophrenia

Paliperidone palmitate leads to lower leaving the study early ‐ any reason Reported by trial author compared with placebo (high certainty).

1 finding from 1 review

Paliperidone palmitate vs placebo

No clinically important change Number of people whose PANSS score either increased or did not decrease by at least 30% from the beginning to the end of the trial · patients with schizophrenia

Paliperidone palmitate probably leads to lower no clinically important change Number of people whose PANSS score… compared with placebo (moderate certainty).

1 finding from 1 review

Paliperidone palmitate vs placebo

Relapse: recurrence of psychotic symptoms Reported by trial author as adverse event · patients with schizophrenia

Paliperidone palmitate probably leads to lower relapse: recurrence of psychotic symptoms Reported by trial author… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Poor compliance with study protocol · people with schizophrenia or like psychosis

The intervention may leads to lower poor compliance with study protocol (low certainty).

1 finding from 1 review

Intervention not reported

Relapse · people with schizophrenia or like psychosis

The intervention may leads to lower relapse (low certainty).

1 finding from 1 review

Intervention not reported

Weight gain (equal or greater then 7% of baseline) · people with schizophrenia or like psychosis

The intervention may leads to higher weight gain (equal or greater then 7% of baseline) (low certainty).

1 finding from 1 review

Intervention not reported

Concomitant medication (Anxiolytic ‐ Lorazepam) · people with schizophrenia or like psychosis

The intervention may leads to lower concomitant medication (Anxiolytic ‐ Lorazepam) (low certainty).

1 finding from 1 review