Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,017 questions · 1,061 findings · 131 reviews

No studies found 193 · 18.2%GRADE not reported 65 · 6.1%Very low 237 · 22.3%Low 325 · 30.6%Moderate 187 · 17.6%High 54 · 5.1%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (chemotherapy delays/discontinuations) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (chemotherapy… compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (unscheduled radiotherapy breaks of 5 or more days) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (unscheduled radiotherapy breaks… compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Oral mucositis (severe) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… may leads to lower oral mucositis (severe) compared with placebo (low certainty).

3 findings from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Number of days of treatment with opioid analgesics · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days of treatment with opioid analgesics compared with placebo; GRADE not reported.

1 finding from 1 review

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

All‐cause mortality during hospital stay · adult patients after liver transplantation.

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes death (during length of initial hospital stay; ITT) compared with standard parenteral nutrition (very low certainty).

1 finding from 1 review

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

Infection (ITT) ‐ mycotic infection · adult patients after liver transplantation.

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes infection (ITT) ‐ mycotic infection compared with standard parenteral nutrition (very low certainty).

1 finding from 1 review

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

Infection (ITT) ‐ infection (overall) · adult patients after liver transplantation.

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes infection (ITT) ‐ infection (overall) compared with standard parenteral nutrition (very low certainty).

1 finding from 1 review

Enteral nutrition via nasojejunal tube plus intravenous glutamine‐dipeptide supplementation vs parenteral nutrition

Acute rejection · adult patients after liver transplantation.

It is very uncertain whether enteral nutrition via nasojejunal tube plus intravenous… changes acute rejection (ITT) compared with standard parenteral nutrition (very low certainty).

1 finding from 1 review