Findings

What do systematic reviews say?

535 questions · 545 findings · 129 reviews · Headline outcomes only

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No studies found 131 · 24%GRADE not reported 30 · 5.5%Very low 123 · 22.6%Low 136 · 25%Moderate 98 · 18%High 27 · 5%

Colchicine vs placebo or usual care

Adverse events within 28 days · people with SARS‐CoV‐2 infection and asymptomatic or mild disease

1 finding from 1 review

Colchicine for the treatment of COVID‐19 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 4412 participants
Low

Colchicine vs placebo or usual care

Serious adverse events within 28 days · people with SARS‐CoV‐2 infection and asymptomatic or mild disease

1 finding from 1 review

Colchicine for the treatment of COVID‐19 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 4412 participants
Moderate

Colchicine vs placebo or usual care

All‐cause mortality up to day 28 · people with SARS‐CoV‐2 infection and asymptomatic or mild disease

1 finding from 1 review

Colchicine for the treatment of COVID‐19 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 4488 participants
Low

Colchicine vs placebo or usual care

Admission to hospital or death within 28 days · people with SARS‐CoV‐2 infection and asymptomatic or mild disease

1 finding from 1 review

Colchicine for the treatment of COVID‐19 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 4488 participants
Moderate

Colchicine vs placebo or usual care

Resolution of symptoms · people with SARS‐CoV‐2 infection and asymptomatic or mild disease

The review found no eligible studies for this question.

1 finding from 1 review

Colchicine for the treatment of COVID‐19 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ultrasound guidance vs no ultrasound

Failed blocks · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

Ultrasound guidance showed no clear difference in failed blocks compared with no ultrasound guidance (moderate certainty).

1 finding from 1 review

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 1789 participants
Moderate

Ultrasound guidance vs no ultrasound

Pain scores at 1 hour after surgery6 · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

1 finding from 1 review

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 982 participants
Moderate

Ultrasound guidance vs no ultrasound

Block duration (0 to 1 day) · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

1 finding from 1 review

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 460 participants
High

Ultrasound guidance vs no ultrasound

Time to perform block · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

1 finding from 1 review

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 680 participants
Moderate

Ultrasound guidance vs no ultrasound

Number of needle passes · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

1 finding from 1 review

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 256 participants
Very low

Ultrasound guidance vs no ultrasound

Minor complications (3 to 6 weeks · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

Ultrasound guidance showed no clear difference in minor complications compared with no ultrasound guidance (low certainty).

1 finding from 1 review

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 896 participants
Low

Ultrasound guidance vs no ultrasound

Major complications · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

Ultrasound guidance showed no clear difference in major complications compared with no ultrasound guidance (moderate certainty).

1 finding from 1 review

The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
RD 0
22 studies · 1576 participants
Moderate

Supervised exercise therapy following vascular intervention vs vascular intervention alone

MWD ‐ change from baseline · people with symptomatic peripheral arterial disease§

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Very low

Supervised exercise therapy following vascular intervention vs vascular intervention alone

Change from baseline in 6MWT (metres) · people with symptomatic peripheral arterial disease§

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 49 participants
Very low

Supervised exercise therapy following vascular intervention vs vascular intervention alone

PFWD (change in metres) (4–40 weeks' · people with symptomatic peripheral arterial disease§

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 87 participants
Very low

Supervised exercise therapy following vascular intervention vs vascular intervention alone

ABI ‐ absolute value · people with symptomatic peripheral arterial disease§

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 110 participants
Very low

Supervised exercise therapy following vascular intervention vs vascular intervention alone

All‐cause mortality · people with symptomatic peripheral arterial disease§

It is very uncertain whether supervised exercise therapy following vascular intervention changes mortality compared with vascular intervention alone (very low certainty).

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
OR 0.92 [0.42, 2]
6 studies · 346 participants
Very low

Supervised exercise therapy following vascular intervention vs vascular intervention alone

Quality of Life: SF‐36 (physical component) · people with symptomatic peripheral arterial disease§

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 105 participants
Very low

Supervised exercise therapy following vascular intervention vs vascular intervention alone

Reintervention · people with symptomatic peripheral arterial disease§

It is very uncertain whether supervised exercise therapy following vascular intervention changes reintervention compared with vascular intervention alone (very low certainty).

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
OR 0.91 [0.23, 3.65]
5 studies · 252 participants
Very low

Summary of findings ‐ dual therapy: tezacaftor plus ivacaftor vs placebo or ivacaftor alone

Survival · adults and children with cystic fibrosis

1 finding from 1 review

Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1132 participants
Low