Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

473 questions · 480 findings · 60 reviews · Headline outcomes only

No studies found 100 · 20.8%GRADE not reported 3 · 0.6%Very low 104 · 21.7%Low 129 · 26.9%Moderate 106 · 22.1%High 38 · 7.9%

Donepezil 10 mg/day vs donepezil 5 mg/day

Clinician‐rated global impression test (improved compared with baseline assessed using CIBIC‐plus at 24 weeks) · people with Alzheimer's disease

Donepezil 10 mg/day showed no clear difference in clinician‐rated global impression test (improved compared with… compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs donepezil 5 mg/day

Secondary outcome: acceptability of treatment · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs donepezil 5 mg/day

Risk for at least one adverse event per patient · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with donepezil 5 mg/day (moderate certainty).

1 finding from 1 review

Sugammadex 2.0 mg/kg vs neostigmine (any dose)

Risk of adverse events and serious adverse eventsb, bradycardia, PONV, and signs of residual neuromuscular blockade · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

The review found no eligible studies for this question.

1 finding from 1 review

10 mg warfarin nomogram vs 5 mg warfarin nomogram

Major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or more units of red cells · patients with venous thromboembolism.

10 mg warfarin nomogram showed no clear difference in major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or… compared with 5 mg warfarin nomogram (moderate certainty).

1 finding from 1 review

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg

Proportion of participants who reported an adverse event · patients with hirsutism

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg showed no clear difference in proportion of participants who reported an adverse event compared with ethinyl estradiol 30 μg + desogestrel 0.15 mg (moderate certainty).

1 finding from 1 review