Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Opioids vs placebo or no treatment

Neurodevelopmental outcomes · neonates with mechanical ventilation

It is very uncertain whether opioids changes neurodevelopmental outcomes (18 to 24 months) compared with placebo or no treatment (very low certainty).

3 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse event: lead failure/ displacement · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

3 findings from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse events: infection · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Palivizumab vs Placebo, no intervention or usual care (with or without placebo)

Hospitalisation due to respiratory‐related illness · children (0 to 24 months)

Palivizumab probably leads to lower hospitalisation due to respiratory‐related illness compared with placebo, no intervention or standard care (moderate certainty).

1 finding from 1 review