What do systematic reviews say?

FAE vs placebo

FAE probably leads to higher common nuisance AEs (not leading to treatment discontinuation) compared with placebo (moderate certainty).

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  RR 4.72 [2.45, 9.08]
  1 study · 99 participants
  Moderate

FAE vs placebo

FAE may leads to higher PASI 50 compared with placebo (low certainty).

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  RR 4.55 [2.8, 7.4]
  2 studies · 247 participants
  Low

FAE vs placebo

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 247 participants
  Low

FAE vs placebo

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

FAE vs MTX

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 51 participants
  Very low

FAE vs MTX

It is very uncertain whether FAE changes AEs leading to treatment discontinuation compared with MTX (very low certainty).

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  RR 0.19 [0.02, 1.53]
  1 study · 51 participants
  Very low

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

It is very uncertain whether summary of findings: Knee orthosis (any type) and exercise changes pain score (VAS) Scale from: 0 to 10 (higher scores mean worse pain) compared with control (exercise only) (very low certainty).

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 234 participants
  Very low

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

It is very uncertain whether summary of findings: Knee orthosis (any type) and exercise changes functional outcomes Scale various 2 compared with control (exercise only) (very low certainty).

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 183 participants
  Very low

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

The review found no eligible studies for this question.

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 51 participants
  Very low

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

The review found no eligible studies for this question.

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

The review found no eligible studies for this question.

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Knee orthosis (any type) and exercise vs control (exercise only)

• Knee orthoses for treating patellofemoral pain syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Very low

Intervention not reported

• Immunotherapy (oral and sublingual) for food allergy to fruits 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Immunotherapy (oral and sublingual) for food allergy to fruits 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Immunotherapy (oral and sublingual) for food allergy to fruits 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Ultrasound or Doppler guidance vs anatomical landmarks

It is very uncertain whether ultrasound or Doppler guidance changes complication rate total compared with anatomical landmark (very low certainty).

• Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization 2015 · Cochrane Headline outcomes only
  RR 0.52 [0.23, 1.17]
  6 studies · 1478 participants
  Very low

Ultrasound or Doppler guidance vs anatomical landmarks

Ultrasound or Doppler guidance showed no clear difference in overall success rate compared with anatomical landmark (low certainty).

• Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization 2015 · Cochrane Headline outcomes only
  RR 1.05 [0.97, 1.13]
  8 studies · 1809 participants
  Low

Ultrasound or Doppler guidance vs anatomical landmarks

• Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 471 participants
  Very low

Ultrasound or Doppler guidance vs anatomical landmarks

Ultrasound or Doppler guidance may leads to lower arterial puncture compared with anatomical landmark (low certainty).

• Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization 2015 · Cochrane Headline outcomes only
  RR 0.21 [0.06, 0.82]
  3 studies · 498 participants
  Low