Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,730 questions · 18,059 findings · 1,282 reviews

No studies found 4,360 · 24.1%GRADE not reported 2,529 · 14%Very low 4,641 · 25.7%Low 4,007 · 22.2%Moderate 2,057 · 11.4%High 465 · 2.6%

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Monthly pegloticase vs placebo

Proportion with complete resolution of a target tophus · participants with tophi in gout

Monthly pegloticase showed no clear difference in proportion with complete resolution of tophi compared with placebo (moderate certainty).

1 finding from 1 review

Monthly pegloticase vs placebo

Joint pain reduction ‐ not reported · participants with tophi in gout

The review found no eligible studies for this question.

1 finding from 1 review

Peer support vs usual care

Psychological distress Measures: ‐ Parenting Stress Index (PSI‐SF) ‐ Psychiatric Symptom Index (PSI) ‐ PSI anxiety sub‐scale ‐ State anxiety inventory ‐ Center for Epidemological Studies Depression Scale (CES‐D) ‐ Profile of Mood State Inventory (... · parents and carers of children with complex needs
1 finding from 1 review

Intervention not reported

Registration behaviour: ICC adjusted (dichotomous) · increasing solid organ donation registration

The intervention may leads to higher registration behaviour: ICC adjusted (dichotomous) (low certainty).

1 finding from 1 review

Intervention not reported

Registration intention (dichotomous) · increasing solid organ donation registration intention

The intervention may leads to higher registration intention (dichotomous) (low certainty).

1 finding from 1 review

Intervention not reported

Registration intention: ICC adjusted (continuous) · increasing solid organ donor registration
1 finding from 1 review