Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,388 questions · 1,444 findings · 167 reviews

No studies found 336 · 23.3%GRADE not reported 67 · 4.6%Very low 419 · 29%Low 395 · 27.4%Moderate 188 · 13%High 39 · 2.7%

TDC vs medical therapy

Primary outcome measure: recurrent stroke (non‐fatal or fatal) stratified by the type of device studied ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: recurrent stroke (non‐fatal or fatal)… compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Death from any cause (secondary outcome 3) · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in secondary outcome: all‐cause mortality at the end of compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Secondary outcome:total serious adverse events at the end of · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in secondary outcome:total serious adverse events at the end of compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Secondary outcome: the incidence of atrial fibrillation · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC probably leads to higher secondary outcome: the incidence of atrial fibrillation compared with medical therapy (moderate certainty).

1 finding from 1 review

TDC vs medical therapy

Time‐to‐event analyses for recurrent stroke · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in time‐to‐event analyses for recurrent stroke compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Time‐to‐event analyses for recurrent stroke stratified by the type of device ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in time‐to‐event analyses for recurrent stroke stratified by the type… compared with medical therapy (moderate certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy probably leads to lower acceptability 1 ‐ proportion of participants withdrawing during… compared with usual care or waiting list (moderate certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy may leads to higher treatment response at end of treatment CGI‐improvement/Global… compared with usual care or waiting list (low certainty).

1 finding from 1 review

Psychological therapy vs enhanced or structured care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy showed no clear difference in acceptability 1 ‐ proportion of participants withdrawing during… compared with enhanced or structured care (moderate certainty).

1 finding from 1 review

Smoking cessation advice vs no smoking cessation counselling, grouped by intensity of intervention

Quit at longest · individuals who smoke cigarettes and are admitted to a hospital for medical or surgical care

It is very uncertain whether smoking cessation counselling changes quit at longest compared with no smoking cessation counselling, grouped by intensity of intervention (very low certainty).

4 findings from 1 review
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