Findings

What do systematic reviews say?

427 questions · 437 findings · 29 reviews · Schizophrenia

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No studies found 77 · 17.6%GRADE not reported 61 · 14%Very low 130 · 29.7%Low 103 · 23.6%Moderate 54 · 12.4%High 12 · 2.7%

ZOTEPINE vs CLOZAPINE

Global state: No clinically important response (as defined by the original studies) · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes global state: No clinically important response (as defined by the… compared with CLOZAPINE (very low certainty).

1 finding from 1 review

Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
RR 8.23 [1.14, 59.17]
1 study · 59 participants
Very low

ZOTEPINE vs CLOZAPINE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with CLOZAPINE (very low certainty).

1 finding from 1 review

Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
RR 20.96 [2.89, 151.9]
2 studies · 116 participants
Very low

ZOTEPINE vs CLOZAPINE

Behaviour: No clinically important response (as defined by the original studies) · patients with schizophrenia

1 finding from 1 review

Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ZOTEPINE vs RISPERIDONE

Mental state: psychopathology Total endpoint data, BPRS (higher score = worse, scale from: 0‐126) · patients with schizophrenia

2 findings from 1 review

Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low
Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

ZOTEPINE vs RISPERIDONE

Global state: No clinically important response (as defined by the original studies) · patients with schizophrenia

1 finding from 1 review

Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

ZOTEPINE vs RISPERIDONE

Adverse effects: Extrapyramidal effects ‐ use of antiparkinson medication ‐ vs 4mg risperidone · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
RR 6 [0.79, 45.42]
1 study · 40 participants
Very low

ZOTEPINE vs RISPERIDONE

Adverse effects: Extrapyramidal effects ‐ use of antiparkinson medication ‐ vs 8mg risperidone · patients with schizophrenia

It is very uncertain whether ZOTEPINE changes adverse effects: Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

Zotepine versus other atypical antipsychotics for schizophrenia 2010 · Cochrane Headline outcomes only
RR 3 [0.69, 13.12]
1 study · 40 participants
Very low