Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 11,779 findings · 747 reviews · Headline outcomes only

No studies found 3,205 · 27.2%GRADE not reported 628 · 5.3%Very low 3,261 · 27.7%Low 2,913 · 24.7%Moderate 1,453 · 12.3%High 319 · 2.7%

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Oral magnesium vs placebo/no treatment

Composite outcome: symptoms of leg cramps (intensity and frequency) Complete recovery: no leg cramps after treatment · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes composite outcome: symptoms of leg cramps (intensity and frequency)… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Side effects (any reported throughout the intervention period) (ALL) · treating leg cramps in pregnancy

Oral magnesium showed no clear difference in side effects ‐ any compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral calcium vs no treatment

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with no treatment (very low certainty).

2 findings from 1 review

Oral calcium vs vitamin C

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with oral vitamin C (very low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

Oral magnesium may leads to higher frequency of leg cramps after treatment: never compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Frequency: 50% reduction in number of leg cramps · treating leg cramps in pregnancy

Oral magnesium may leads to higher frequency: 50% reduction in number of leg cramps compared with placebo/no treatment (low certainty).

1 finding from 1 review