Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Comparison 1: community‐based antibiotic delivery vs usual care

Sepsis‐specific mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery showed no clear difference in sepsis‐specific mortality compared with standard care (low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ first dose and referral · neonates with sepsis

Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ full course · neonates with sepsis

It is very uncertain whether comparison 1: referral or full course of antibiotics changes neonatal mortality ‐ full course compared with standard care (very low certainty).

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ injectable antibiotic · neonates with sepsis

Comparison 1: route of antibiotic probably leads to lower neonatal mortality ‐ injectable antibiotic compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis

Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).

1 finding from 1 review

Community health educational interventions vs control

Neonatal mortality · developing countries

Community health educational interventions may leads to lower neonatal mortality compared with control (low certainty).

2 findings from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Both one‐to‐one and group counselling · developing countries

Community health educational one‐to‐one and group and both… probably leads to lower early neonatal mortality ‐ Both one‐to‐one and group counselling compared with control (moderate certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Late neonatal mortality ‐ Group counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes late neonatal mortality ‐ Group counselling compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Late neonatal mortality ‐ Both group and one‐to‐one counselling · developing countries

Community health educational one‐to‐one and group and both… probably leads to lower late neonatal mortality ‐ Both group and one‐to‐one counselling compared with control (moderate certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Perinatal mortality ‐ One‐to‐one counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes perinatal mortality ‐ One‐to‐one counselling compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Perinatal mortality · developing countries

Community health educational one‐to‐one and group and both… may leads to lower perinatal mortality ‐ Group counselling compared with control (low certainty).

2 findings from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Neonatal mortality · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes neonatal mortality ‐ Education provided during ANC period only compared with control (very low certainty).

3 findings from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during ANC period only · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during ANC period only compared with control (very low certainty).

1 finding from 1 review

Community health educational interventions vs control

Early neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes early neonatal mortality compared with control (very low certainty).

2 findings from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during PNC period only · developing countries

Community health educational ANC period and PNC period and both… showed no clear difference in early neonatal mortality ‐ Education provided during PNC period only compared with control (moderate certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during both ANC and PNC periods · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during both ANC and… compared with control (very low certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Late neonatal mortality ‐ Education provided during ANC period only · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes late neonatal mortality ‐ Education provided during ANC period only compared with control (very low certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Late neonatal mortality ‐ Education provided during both ANC and PNC periods · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes late neonatal mortality ‐ Education provided during both ANC and PNC… compared with control (very low certainty).

1 finding from 1 review