Findings

What do systematic reviews say?

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

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No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Eculizumab vs placebo or alternative treatment

Requirement for KRT · children and adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
100 participants
Very low

Eculizumab vs placebo or alternative treatment

Remission · children and adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
100 participants
Very low

Eculizumab vs placebo or alternative treatment

Change in eGFR · children and adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
88 participants
Very low

Eculizumab vs placebo or alternative treatment

Health‐related quality of life · children and adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
100 participants
Very low

Eculizumab vs placebo or alternative treatment

Adverse events · children and adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
100 participants
Very low

Eculizumab vs placebo or alternative treatment

Meningococcal infection · children and adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
100 participants
Very low

Ravulizumab vs placebo or alternative treatment

Death · adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
58 participants
Very low

Ravulizumab vs placebo or alternative treatment

Requirement for KRT · adults with aHUS

1 finding from 1 review

Interventions for atypical haemolytic uraemic syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
56 participants
Very low

Bethanechol vs placebo

Rate of spontaneous voiding recovery 1 week after surgery

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Suprapubic catheterisation vs intermittent self‐catheterisation

Time after surgery to post‐void residual volume of urine ≤ 50 mL (days)

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Suprapubic catheterisation vs intermittent self‐catheterisation

Adverse events (acute complication after surgery)

It is very uncertain whether suprapubic catheterisation changes adverse events (acute complication after surgery) compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
RR 0.77 [0.24, 2.49]
1 study · 71 participants
Very low

Suprapubic catheterisation vs intermittent self‐catheterisation

Post‐void residual urine volume (mL) at 1 month after surgery

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Suprapubic catheterisation vs intermittent self‐catheterisation

Urinary tract infection

It is very uncertain whether suprapubic catheterisation changes urinary tract infections in the first month after surgery compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
RR 0.77 [0.53, 1.13]
2 studies · 95 participants
Very low

Suprapubic catheterisation vs intermittent self‐catheterisation

Subjective urinary symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bethanechol vs placebo

QoL

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bethanechol vs placebo

Time after surgery to post‐void residual volume of urine ≤ 50 mL (days)

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bethanechol vs placebo

Adverse events

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bethanechol vs placebo

Post‐void residual urine volume (mL) at 1 month after surgery

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Very low

Bethanechol vs placebo

Urinary tract infection

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bethanechol vs placebo

Subjective urinary symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found