Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,749 questions · 14,273 findings · 834 reviews

No studies found 3,655 · 25.6%GRADE not reported 2,115 · 14.8%Very low 3,646 · 25.5%Low 3,034 · 21.3%Moderate 1,503 · 10.5%High 320 · 2.2%

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Topical clobetasol propionate vs Topical tacrolimus

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

Intraoperative pain · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

It is very uncertain whether electrical counter-stimulation device (DentalVibe) changes self- or observational assessment of intraoperative… compared with conventional treatment (no stimulation) (very low certainty).

1 finding from 1 review

Hypnosis vs Conventional treatment

Patient satisfaction: measured by questionnaires · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Topical triamcinolone acetonide vs Topical ciclosporin

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide led to lower adverse effects compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Intralesional betamethasone vs intralesional injections of triamcinolone acetonide

Clinical score (14 days) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether intralesional betamethasone changes clinical score (14 days) compared with intralesional triamcinolone acetonide (very low certainty).

1 finding from 1 review

The wand (computer-controlled LA delivery system) vs other local anaesthetic

Patient satisfaction: measured by questionnaires · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

The wand (computer-controlled LA delivery system) vs other local anaesthetic

Patient perception: pain · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The wand (computer-controlled LA delivery system) showed no clear difference in pain perception during the intervention (pooled) compared with traditional local anaesthetic; GRADE not reported.

1 finding from 1 review

Counter-stimulation or distraction vs Conventional treatment

Successful LA/painless treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Antimicrobial coolant A (chlorhexidine) vs povidone‐iodine

Reduction in level of contamination in aerosols (CFU): chlorhexidine vs povidone iodine coolant during ultrasonic scaling · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether antimicrobial coolant A (chlorhexidine) changes reduction in level of contamination in aerosols (CFU): chlorhexidine… compared with antimicrobial coolant B (povidone iodine) (very low certainty).

1 finding from 1 review

Antimicrobial coolant A (chlorhexidine) vs Antimicrobial coolant B (cinnamon extract)

Reduction in level of contamination in aerosols (CFU): chlorhexidine vs cinnamon extract coolant during ultrasonic scaling · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether antimicrobial coolant A (chlorhexidine) changes reduction in level of contamination in aerosols (CFU): chlorhexidine… compared with antimicrobial coolant B (cinnamon extract) (very low certainty).

1 finding from 1 review

Pre-cooling of the injection site vs Conventional treatment

Completion of dental treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Audiovisual distraction vs Conventional treatment

Anxiety · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Audiovisual distraction led to lower pre- and post-operative anxiety measures (Modified Child Dental… compared with conventional treatment; GRADE not reported.

1 finding from 1 review

The wand (computer-controlled LA delivery system) vs other local anaesthetic

Successful LA/painless treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Camouflage syringe vs Conventional syringe

Patient satisfaction: measured by questionnaires · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Hypnosis vs Conventional treatment

Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

High-volume evacuation (HVE) vs No HVE

Reduction in level of contamination in aerosols (CFU) at more than 1 foot from oral cavity (CCT) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

High-volume evacuation (HVE) led to lower reduction in level of contamination in aerosols (CFU) at more than 1… compared with no HVE; GRADE not reported.

1 finding from 1 review

Audiovisual distraction vs Conventional treatment

Self- or observational assessment of intraoperative distress/pain/acceptance of treatment during provision of LA: pain-related behaviour during LA (negative vs positive behaviour; Frankl Behaviour Rating Scale) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

It is very uncertain whether audiovisual distraction changes self- or observational assessment of intraoperative… compared with conventional treatment (very low certainty).

1 finding from 1 review