Findings

What do systematic reviews say?

4,752 questions · 6,648 findings · 688 reviews

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No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Intervention not reported

Total studies: 17 RCTsTotal participants: 3972 · patients with moderate to severe eczema

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
17 studies · 3972 participants
GRADE not reported

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

The intervention probably leads to lower QAW039 (1 RCT; 76 participants) (moderate certainty).

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
RR 0.09 [0.01, 0.76]
1 study · 39 participants
Moderate

Intervention not reported

Dupilumab (9 RCTs; 1663 participants) · patients with moderate to severe eczema

The intervention may leads to lower dupilumab (9 RCTs; 1663 participants) (low certainty).

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
RR 0.37 [0.23, 0.59]
9 studies · 1663 participants
Low

Intervention not reported

Timapiprant (1 RCT; 70 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in timapiprant (1 RCT; 70 participants) (low certainty).

1 finding from 1 review

Systemic treatments for eczema: a network meta‐analysis 2020 · Cochrane Headline outcomes only
RR 0.34 [0.07, 1.62]
1 study · 70 participants
Low

Intervention not reported

Supportive care only*** (1 RCT, 81 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
GRADE not reported

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention showed no clear difference in TMZ (3 RCTs, 538 participants) (low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.95 [0.71, 1.26]
3 studies · 538 participants
Low

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention leads to lower CRT (2 RCTs; 635 participants) (high certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.67 [0.56, 0.8]
2 studies · 635 participants
High

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention probably leads to lower BEV_CRT (1 RCT; 73 participants) (moderate certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.56 [0.31, 0.99]
1 study · 73 participants
Moderate

Intervention not reported

RT 60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 60 participants
GRADE not reported

Intervention not reported

RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention showed no clear difference in RT 40 (4 RCTs; 930 participants) (low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.94 [0.72, 1.23]
4 studies · 40 participants
Low

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes BEV_RT (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 1.01 [0.58, 1.79]
1 study · 75 participants
Very low

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes TMZ (3 RCTs, 538 participants) (very low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.89 [0.71, 1.11]
3 studies · 538 participants
Very low

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention may leads to lower CRT (2 RCTs; 635 participants) (low certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.63 [0.46, 0.87]
2 studies · 635 participants
Low

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.52 [0.28, 0.98]
1 study · 73 participants
GRADE not reported

Intervention not reported

RT vs supportive care only · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Intervention not reported

RT60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…

The intervention probably leads to lower RT60 (5 RCTs; 713 participants) (moderate certainty).

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.47 [0.29, 0.76]
5 studies · 60 participants
Moderate

Intervention not reported

Hypofractionated RT vs standard RT (60Gy/30 fractions) · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 85 participants
Low

Intervention not reported

TMZ vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 306 participants
Moderate

Intervention not reported

CRT vs RT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 562 participants
GRADE not reported

Intervention not reported

BEV_CRT vs CRT · elderly people with newly diagnosed glioblastoma Interventions: one treatment option Comparison: an alternative treatment option

1 finding from 1 review

Treatment of newly diagnosed glioblastoma in the elderly: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 73 participants
GRADE not reported