Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intervention not reported

GBR830 (1 RCT; 46 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in GBR830 (1 RCT; 46 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Azathiopine (AZA) (1 RCT; 41 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in azathiopine (AZA) (1 RCT; 41 participants) (low certainty).

1 finding from 1 review

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QAW039 (1 RCT; 76 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

CsAI (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes csAI (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 17 RCTsTotal participants: 3972 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

The intervention probably leads to lower QAW039 (1 RCT; 76 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

Dupilumab (9 RCTs; 1663 participants) · patients with moderate to severe eczema

The intervention may leads to lower dupilumab (9 RCTs; 1663 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Timapiprant (1 RCT; 70 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in timapiprant (1 RCT; 70 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Supportive care only*** (1 RCT, 81 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
1 finding from 1 review

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention showed no clear difference in TMZ (3 RCTs, 538 participants) (low certainty).

1 finding from 1 review

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention leads to lower CRT (2 RCTs; 635 participants) (high certainty).

1 finding from 1 review

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention probably leads to lower BEV_CRT (1 RCT; 73 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention showed no clear difference in RT 40 (4 RCTs; 930 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes BEV_RT (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes TMZ (3 RCTs, 538 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention may leads to lower CRT (2 RCTs; 635 participants) (low certainty).

1 finding from 1 review