Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,752 questions · 6,648 findings · 688 reviews

No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Intervention not reported

Anti‐thymocyte globulin plus glucocorticosteroids (3 RCTs; 152 participants) · adults undergoing liver transplantation

It is very uncertain whether the intervention changes anti‐thymocyte globulin plus glucocorticosteroids (3 RCTs; 152… (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Tezepelumab (1 RCT; 56 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in tezepelumab (1 RCT; 56 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

PF‐04965842 (1 RCT; 211 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes PF‐04965842 (1 RCT; 211 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Tralokinumab (1 RCT; 153 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes tralokinumab (1 RCT; 153 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Apremilast (1 RCT; 121 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in apremilast (1 RCT; 121 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Baricitinib (1 RCT; 75 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes baricitinib (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 6 RCTsTotal participants: 1720 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Dupilumab (3 RCTs; 1082 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in dupilumab (3 RCTs; 1082 participants) (low certainty).

1 finding from 1 review