Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,751 questions · 12,775 findings · 807 reviews · Headline outcomes only

No studies found 3,413 · 26.7%GRADE not reported 709 · 5.5%Very low 3,483 · 27.3%Low 3,165 · 24.8%Moderate 1,628 · 12.7%High 377 · 3%

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Azathioprine vs methotrexate

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Death at 6 months · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in death at 6 months compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Relapse · adults with renal vasculitis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics vs placebo

Remission · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in remission at one year compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Discontinuation of medication due to adverse events · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in adverse events causing study drug discontinuation compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Urinary tract infection · adults with renal vasculitis for maintenance therapy

Antibiotics may leads to lower infection (urinary tract infection) compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Total number of adverse events · adults with renal vasculitis

The intervention showed no clear difference in total number of adverse events (low certainty).

1 finding from 1 review