Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

444 questions · 453 findings · 34 reviews · Headline outcomes only

No studies found 117 · 25.8%GRADE not reported 17 · 3.8%Very low 176 · 38.9%Low 96 · 21.2%Moderate 34 · 7.5%High 13 · 2.9%

HALOPERIDOL vs BENZODIAZEPINE: a. FLUNITRAZEPAM

Specific behaviours ‐ Aggression 50% reduction in OAS score at 90 minutes · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes specific behaviours ‐ aggression 50% reduction in OAS score at 90… compared with BENZODIAZEPINE: a. FLUNITRAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Global outcome: no overall improvement ‐ at 30 minutes · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 60 minutes compared with BENZODIAZEPINE: b. LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Adverse effects: specific ‐ dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ dystonia (only reported if occurred in… compared with BENZODIAZEPINE: b. LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ hypertonia/rigidity (only reported if… compared with BENZODIAZEPINE: b. LORAZEPAM (very low certainty).

1 finding from 1 review