Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

480 questions · 494 findings · 38 reviews

No studies found 118 · 23.9%GRADE not reported 54 · 10.9%Very low 176 · 35.6%Low 99 · 20%Moderate 34 · 6.9%High 13 · 2.6%

HALOPERIDOL vs RISPERIDONE

Specific behaviours ‐ agitation >50% reduction in PANSS‐EC score · patients with psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in specific behaviours ‐ agitation >50% reduction in PANSS‐EC score compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Global outcome ‐ rated as severe ‐ CGI‐S · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome ‐ rated as severe ‐ CGI‐S compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Adverse effects: specific ‐ acute dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ acute dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: h. THIOTHIXENE

Global outcome No improvement at 1 hour · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome No improvement at 1 hour compared with OTHER ANTIPSYCHOTIC: i. THIOTHIXENE (very low certainty).

1 finding from 1 review