Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

628 questions · 651 findings · 39 reviews · Skin

No studies found 167 · 25.7%GRADE not reported 47 · 7.2%Very low 80 · 12.3%Low 139 · 21.4%Moderate 174 · 26.7%High 44 · 6.8%

Injectable fillers vs placebo or no treatment

Investigator‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

Injectable fillers showed no clear difference in investigator‐assessed adverse events (short‐term) N of participants… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metronidazole vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azelaic acid vs placebo

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Azelaic acid leads to higher participant‐assessed improvement in rosacea severity Marked… compared with placebo (high certainty).

1 finding from 1 review

Azelaic acid vs placebo

Proportion of participants with adverse event · Participants with rosacea
1 finding from 1 review

Azelaic acid vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Azelaic acid leads to higher physician‐assessed improvement in rosacea severity compared with placebo (high certainty).

1 finding from 1 review

Azelaic acid vs placebo

Time needed until improvement of the skin lesions · Participants with rosacea
1 finding from 1 review

Azelaic acid vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

Participant‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review

Topical ivermectin vs placebo

Assessment of erythema or telangiectasia ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Topical ivermectin vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

Proportion of participants with adverse event · Participants with rosacea

Metronidazole showed no clear difference in proportion of participants with adverse event compared with placebo (high certainty).

1 finding from 1 review