Findings

What do systematic reviews say?

697 questions · 708 findings · 47 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 263 · 37.1%GRADE not reported 12 · 1.7%Very low 146 · 20.6%Low 168 · 23.7%Moderate 98 · 13.8%High 21 · 3%

Sildenafil vs placebo

Detumescence · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Reduction in frequency of priapism · men and boys with SCD and stuttering priapism

Sildenafil showed no clear difference in reduction in frequency of priapism compared with placebo (low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.58 [0.07, 4.95]
1 study · 13 participants
Low

Sildenafil vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Summary of findings ‐ Niprisan® vs placebo

Frequency, severity or duration of painful crises · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
70 participants
Low

Summary of findings ‐ Ciklavit® vs placebo

Frequency of hospital admissions from severe complications of SCD · people with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Ciklavit® vs placebo

Any adverse events including hepatic and renal toxicity · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Low

Summary of findings ‐ Ciklavit® vs placebo

Frequency of blood transfusion · people with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Ciklavit® vs placebo

Level of anaemia: packed cell volume · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Low

Summary of findings ‐ Ciklavit® vs placebo

Quality of life measures · people with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency, severity or duration of painful crises · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency of severe complications of SCD · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency of hospital admissions from severe complications of SCD · children with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Pfaffia paniculata vs placebo

Any adverse events including hepatic and renal toxicity · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency of blood transfusion · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Niprisan® vs placebo

Frequency of severe complications of SCD · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
70 participants
Low

Summary of findings ‐ Pfaffia paniculata vs placebo

Level of anaemia: packed cell volume · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Quality of life measures · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Number of sickle cells, peripheral erythroblasts and reticulocytes · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Niprisan® vs placebo

Frequency of hospital admissions from severe complications of SCD · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
70 participants
Low

Summary of findings ‐ Niprisan® vs placebo

Any adverse events including hepatic and renal toxicity · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
80 participants
Low